Increased 25(OH)D3 level in redheaded people: Could redheadedness be an adaptation to temperate climate?
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10420721" target="_blank" >RIV/00216208:11310/20:10420721 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00023761:_____/20:N0000005
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=bpgtShltvv" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=bpgtShltvv</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/exd.14119" target="_blank" >10.1111/exd.14119</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Increased 25(OH)D3 level in redheaded people: Could redheadedness be an adaptation to temperate climate?
Popis výsledku v původním jazyce
About 1-2% of European population are redheaded, meaning they synthesize more pheomelanin than eumelanin, the main melanin pigment in humans. Several muta- tions could be responsible for this phenotype. It has been suggested that corre- sponding mutations spread in Europe due to a founder effect shaped either by a relaxation of selection for dark, UV-protective phenotypes or by sexual selection in favour of rare phenotypes. In our study, we investigated the levels of vitamin D precursor 25(OH)D3 (calcidiol) and folic acid in the blood serum of 73 redheaded and 130 non-redheaded individuals. In redheaded individuals, we found higher 25(OH)D3 concentrations and approximately the same folic acid concentrations as in non-red- headed subjects. 25(OH)D3 concentrations correlated with the intensity of hair red- ness measured by two spectrophotometric methods and estimated by participants themselves and by independent observers. In non-redheaded individuals, 25(OH)D3 levels covaried with the amount of sun exposure and intensity of suntan while in redheaded individuals, this was not the case. It suggests that increased 25(OH)D3 levels in redheaded individuals are due to differences in physiology rather than in behaviour. We also found that folic acid levels increased with age and the intensity of baldness and decreased with the frequency of visiting tanning salons. Our results suggest that the redheaded phenotype could be an evolutionary adaptation for suf- ficient photosynthesis of provitamin D in conditions of low intensity of UVB radiation in central and northern parts of Europe.
Název v anglickém jazyce
Increased 25(OH)D3 level in redheaded people: Could redheadedness be an adaptation to temperate climate?
Popis výsledku anglicky
About 1-2% of European population are redheaded, meaning they synthesize more pheomelanin than eumelanin, the main melanin pigment in humans. Several muta- tions could be responsible for this phenotype. It has been suggested that corre- sponding mutations spread in Europe due to a founder effect shaped either by a relaxation of selection for dark, UV-protective phenotypes or by sexual selection in favour of rare phenotypes. In our study, we investigated the levels of vitamin D precursor 25(OH)D3 (calcidiol) and folic acid in the blood serum of 73 redheaded and 130 non-redheaded individuals. In redheaded individuals, we found higher 25(OH)D3 concentrations and approximately the same folic acid concentrations as in non-red- headed subjects. 25(OH)D3 concentrations correlated with the intensity of hair red- ness measured by two spectrophotometric methods and estimated by participants themselves and by independent observers. In non-redheaded individuals, 25(OH)D3 levels covaried with the amount of sun exposure and intensity of suntan while in redheaded individuals, this was not the case. It suggests that increased 25(OH)D3 levels in redheaded individuals are due to differences in physiology rather than in behaviour. We also found that folic acid levels increased with age and the intensity of baldness and decreased with the frequency of visiting tanning salons. Our results suggest that the redheaded phenotype could be an evolutionary adaptation for suf- ficient photosynthesis of provitamin D in conditions of low intensity of UVB radiation in central and northern parts of Europe.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
Návaznosti výsledku
Projekt
<a href="/cs/project/GA18-13692S" target="_blank" >GA18-13692S: Udržování Rh polymorfismu v populaci moderního člověka selekcí ve prospěch heterozygotů – vliv genotypu na fertilitu a viabilitu</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Experimental Dermatology
ISSN
0906-6705
e-ISSN
—
Svazek periodika
29
Číslo periodika v rámci svazku
7
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
12
Strana od-do
598-609
Kód UT WoS článku
000543087100001
EID výsledku v databázi Scopus
2-s2.0-85087170082