Biocompatibility of TiO2 prolate nanospheroids as a potential photosenzitizer in therapy of cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10442514" target="_blank" >RIV/00216208:11310/20:10442514 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/20:00532061

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=G2P_CqKsu~" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=G2P_CqKsu~</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11051-020-04899-3" target="_blank" >10.1007/s11051-020-04899-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biocompatibility of TiO2 prolate nanospheroids as a potential photosenzitizer in therapy of cancer

Popis výsledku v původním jazyce

TiO2 prolatenanospheroids (PNSs) may be photosensitizers (PSs), which act by catalyzation of hydroxyl radical (.OH) formation upon light illumination. Radical .OH might, in turn, contribute to killing of cancer cells. On the other hand, there is great concern about toxicity in the dark of TiO2 nanoparticles in general. In this work, we have investigated the biocompatibility of TiO2 PNSs of the anatase crystal form (length between 100 and 300 nm and width 50 nm) in the dark with immune cells and light-induced cytotoxicity on several cancer cell lines. The effects of the treatment of different cell lines with several concentrations of TiO2 PNSs suspensions showed the specifics of cells&apos; viability and the intracellular localization. The results of in vitro studies obtained by cytotoxicity assays adjusted to individual cell lines&apos; metabolism point towards the biocompatibility of TiO2 PNSs at low and moderate concentrations in the dark, which neither kill the cells, nor induce activation of the immune system cells. Laser scanning confocal microscopy revealed that PNSs are taken up by cells, and insight into the intracellular distribution was obtained in this study.

Název v anglickém jazyce

Biocompatibility of TiO2 prolate nanospheroids as a potential photosenzitizer in therapy of cancer

Popis výsledku anglicky

TiO2 prolatenanospheroids (PNSs) may be photosensitizers (PSs), which act by catalyzation of hydroxyl radical (.OH) formation upon light illumination. Radical .OH might, in turn, contribute to killing of cancer cells. On the other hand, there is great concern about toxicity in the dark of TiO2 nanoparticles in general. In this work, we have investigated the biocompatibility of TiO2 PNSs of the anatase crystal form (length between 100 and 300 nm and width 50 nm) in the dark with immune cells and light-induced cytotoxicity on several cancer cell lines. The effects of the treatment of different cell lines with several concentrations of TiO2 PNSs suspensions showed the specifics of cells&apos; viability and the intracellular localization. The results of in vitro studies obtained by cytotoxicity assays adjusted to individual cell lines&apos; metabolism point towards the biocompatibility of TiO2 PNSs at low and moderate concentrations in the dark, which neither kill the cells, nor induce activation of the immune system cells. Laser scanning confocal microscopy revealed that PNSs are taken up by cells, and insight into the intracellular distribution was obtained in this study.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10600 - Biological sciences

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Nanoparticle Research

ISSN

1388-0764

e-ISSN

—

Svazek periodika

22

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

12

Strana od-do

175

Kód UT WoS článku

000547506100001

EID výsledku v databázi Scopus

2-s2.0-85087054250