Synthesis and antimicrobial activity of novel kojyl carbamates

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10457686" target="_blank" >RIV/00216208:11310/20:10457686 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=KZqrBMA7pd" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=KZqrBMA7pd</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis and antimicrobial activity of novel kojyl carbamates

Popis výsledku v původním jazyce

Novel kojyl carbamates of amantadine, rimantadine and oseltamivir were synthesized and assayed to evaluate their antimicrobial activity. The newly compounds were prepared by using EDC/HOBt method at preliminary activation of kojic acid. The structures of the synthesized kojyl derivatives were confirmed by mp, UV, IR (ATR)umax, ESI-MS. According to the antimicrobial activity studies performed in vitro, kojyl carbamate of rimantadine (4) displayed the highest antibacterial activity (MIC: 31 μg/mL) against two Gram-positive (Staphylococcus aureus, Bacillus subtilis) bacteria. Moreover, this compound (4) showed about 4-fold better activity against two Gram-negative bacteria tested (Escherichia coli, Pseudomonas aeruginosa). Amongst the examined kojyl carbamates, the rimantadine derivative of kojic acid (4) exhibited the highest antifungal activity (Candida albicans) as well.

Název v anglickém jazyce

Synthesis and antimicrobial activity of novel kojyl carbamates

Popis výsledku anglicky

Novel kojyl carbamates of amantadine, rimantadine and oseltamivir were synthesized and assayed to evaluate their antimicrobial activity. The newly compounds were prepared by using EDC/HOBt method at preliminary activation of kojic acid. The structures of the synthesized kojyl derivatives were confirmed by mp, UV, IR (ATR)umax, ESI-MS. According to the antimicrobial activity studies performed in vitro, kojyl carbamate of rimantadine (4) displayed the highest antibacterial activity (MIC: 31 μg/mL) against two Gram-positive (Staphylococcus aureus, Bacillus subtilis) bacteria. Moreover, this compound (4) showed about 4-fold better activity against two Gram-negative bacteria tested (Escherichia coli, Pseudomonas aeruginosa). Amongst the examined kojyl carbamates, the rimantadine derivative of kojic acid (4) exhibited the highest antifungal activity (Candida albicans) as well.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

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OECD FORD obor

10401 - Organic chemistry

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bulgarian Chemical Communications

ISSN

0861-9808

e-ISSN

2534-9899

Svazek periodika

52

Číslo periodika v rámci svazku

Special issue A

Stát vydavatele periodika

BG - Bulharská republika

Počet stran výsledku

7

Strana od-do

23-29

Kód UT WoS článku

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EID výsledku v databázi Scopus

2-s2.0-85087050345