Boron cluster compounds as new chemical leads for antimicrobial therapy

Kód výsledku v IS VaVaI

RIV/00216208:11310/21:10438533 - isvavai.cz

Výsledek na webu

https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=FlP9jN7kDT

DOI - Digital Object Identifier

10.1016/j.ccr.2020.213684

Jazyk výsledku

angličtina

Název v původním jazyce

Boron cluster compounds as new chemical leads for antimicrobial therapy

Popis výsledku v původním jazyce

Boron cluster compounds are inorganic compounds with chemical compositions and structures vastly different from those of organic compounds, albeit with the ability to form a rich family of molecules. Boron cluster compounds are 3-dimensional, aromatic compounds with 3-center-2-electron (3c2e) bonds (e.g., B-B-B and B-B-C). They are not found in living organisms, which explains the lack of enzymatic systems capable of metabolizing boron cluster compounds and their high biological stability. In addition, boron cluster compounds and organic compounds interact with components of biological systems, such as lipid membranes and proteins, through different mechanisms. As a result, derivatives of boron cluster compounds show the same efficacy against standard and multi-drug resistant strains of pathogens. Moreover, they show anti-biofilm activity and are less prone to trigger drug resistance. In conclusion, boron cluster compounds have the potential to become new chemical leads in antimicrobial therapy because their derivatives show promising antimicrobial activity and low sensitivity to both genetic and phenotypic mechanisms of pathogen resistance.

Název v anglickém jazyce

Boron cluster compounds as new chemical leads for antimicrobial therapy

Popis výsledku anglicky

Boron cluster compounds are inorganic compounds with chemical compositions and structures vastly different from those of organic compounds, albeit with the ability to form a rich family of molecules. Boron cluster compounds are 3-dimensional, aromatic compounds with 3-center-2-electron (3c2e) bonds (e.g., B-B-B and B-B-C). They are not found in living organisms, which explains the lack of enzymatic systems capable of metabolizing boron cluster compounds and their high biological stability. In addition, boron cluster compounds and organic compounds interact with components of biological systems, such as lipid membranes and proteins, through different mechanisms. As a result, derivatives of boron cluster compounds show the same efficacy against standard and multi-drug resistant strains of pathogens. Moreover, they show anti-biofilm activity and are less prone to trigger drug resistance. In conclusion, boron cluster compounds have the potential to become new chemical leads in antimicrobial therapy because their derivatives show promising antimicrobial activity and low sensitivity to both genetic and phenotypic mechanisms of pathogen resistance.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

LTAIN19078: Nanostrukturované micely s jedním či více kompartmenty a odezvou na vnější podněty tvořené blokovými kopolymery: Materiály a aplikace

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Coordination Chemistry Reviews

ISSN

0010-8545

e-ISSN

—

Svazek periodika

431

Číslo periodika v rámci svazku

March

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

213684

Kód UT WoS článku

000635556300008

EID výsledku v databázi Scopus

2-s2.0-85098194758