Functionalization of decavanadate anion by coordination to cobalt(II): Binding to proteins, cytotoxicity, and water oxidation catalysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10465377" target="_blank" >RIV/00216208:11310/23:10465377 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=_JeterFiBi" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=_JeterFiBi</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jinorgbio.2022.112067" target="_blank" >10.1016/j.jinorgbio.2022.112067</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Functionalization of decavanadate anion by coordination to cobalt(II): Binding to proteins, cytotoxicity, and water oxidation catalysis

Popis výsledku v původním jazyce

A series of five decavanadates (V(10)) using a simple, one-pot synthesis, adhering to the model template: transition metal ion - decavanadate - ligands:(Hnicotinamide)(2){[Co(H2O)(3)(nicotinamide)(2)](2)[μ-V10O28]} . 6H2O (1), {[Co(H2O)(4)(isonicotinamide)(2)](3)}V10O28 . 4H2O (2), {[Co(H2O)(4)](2)[Co(H2O)2(μ-pyrazinamide)2][μ-V10O28]} . 4H2O (3) {[Co(H2O)(4)(μ-pyrazinamide)](3).V10O28} . 4H2O (4), and (NH4)(2){[Ni(H2O)(4)(2-hydroxyethylpyridine)](2)}V10O28 . 2H2O (5) was synthesized. X-ray analysis reveals that 1 and 3 are decavanadato complexes, while 2, 4 and 5 are decavanadate complex salts. Moreover, 3 is the first example of a polymeric decavanadato complex, employing direct coordination with the metal center and the organic ligand, in toto. From the solution studies using V-51 NMR spectroscopy, it was decoded that 1 and 3 stay stable in the model buffer solution and aqueous media. Binding to model proteins, cytotoxicity and water oxidation catalysis (WOC) was studied primarily for 1 and 3 and concluded that neither 1 nor 3 have an interaction with the model proteins thaumatin, lysozyme and pro-teinase K, because of the presence of the organic ligands in the Co(II) center, any further interplay with the proteins was blocked. Cytotoxicity studies reveal that 1 is 40% less toxic (0.05 mM) and 26% less toxic (0.1 mM) than the uncoordinated V(10) with human cell lines A549 and HeLa respectively. In WOC, 1 performed superior activity, by evolving 143.37 nmol of O2 which is 700% (9-fold) increase than the uncoordinated V(10).

Název v anglickém jazyce

Functionalization of decavanadate anion by coordination to cobalt(II): Binding to proteins, cytotoxicity, and water oxidation catalysis

Popis výsledku anglicky

A series of five decavanadates (V(10)) using a simple, one-pot synthesis, adhering to the model template: transition metal ion - decavanadate - ligands:(Hnicotinamide)(2){[Co(H2O)(3)(nicotinamide)(2)](2)[μ-V10O28]} . 6H2O (1), {[Co(H2O)(4)(isonicotinamide)(2)](3)}V10O28 . 4H2O (2), {[Co(H2O)(4)](2)[Co(H2O)2(μ-pyrazinamide)2][μ-V10O28]} . 4H2O (3) {[Co(H2O)(4)(μ-pyrazinamide)](3).V10O28} . 4H2O (4), and (NH4)(2){[Ni(H2O)(4)(2-hydroxyethylpyridine)](2)}V10O28 . 2H2O (5) was synthesized. X-ray analysis reveals that 1 and 3 are decavanadato complexes, while 2, 4 and 5 are decavanadate complex salts. Moreover, 3 is the first example of a polymeric decavanadato complex, employing direct coordination with the metal center and the organic ligand, in toto. From the solution studies using V-51 NMR spectroscopy, it was decoded that 1 and 3 stay stable in the model buffer solution and aqueous media. Binding to model proteins, cytotoxicity and water oxidation catalysis (WOC) was studied primarily for 1 and 3 and concluded that neither 1 nor 3 have an interaction with the model proteins thaumatin, lysozyme and pro-teinase K, because of the presence of the organic ligands in the Co(II) center, any further interplay with the proteins was blocked. Cytotoxicity studies reveal that 1 is 40% less toxic (0.05 mM) and 26% less toxic (0.1 mM) than the uncoordinated V(10) with human cell lines A549 and HeLa respectively. In WOC, 1 performed superior activity, by evolving 143.37 nmol of O2 which is 700% (9-fold) increase than the uncoordinated V(10).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Inorganic Biochemistry

ISSN

0162-0134

e-ISSN

1873-3344

Svazek periodika

239

Číslo periodika v rámci svazku

February

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

112067

Kód UT WoS článku

000913192100003

EID výsledku v databázi Scopus

2-s2.0-85142321312