Interactions of triazole terconazole with copper and zinc cations

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10465603" target="_blank" >RIV/00216208:11310/23:10465603 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60460709:41210/23:94806 RIV/00216208:11110/23:10465603 RIV/00216208:11510/23:10465603

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=TencH5ZkFu" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=TencH5ZkFu</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00706-023-03074-3" target="_blank" >10.1007/s00706-023-03074-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Interactions of triazole terconazole with copper and zinc cations

Popis výsledku v původním jazyce

Terconazole is one of the triazole derivatives with an antifungal effect. It is used locally to treat vaginal yeast infections. Terconazole could interact with copper cations in the vagina or uterus of women who use an intrauterine device releasing copper cations. Other triazole derivatives in complexes with copper cations differ in their properties like toxicity or mobility. Cu2+ can be reduced in the presence of triazoles, which can lead to a Fenton-like reaction and the production of free radicals. Thus, the Cu2+/Cu+ terconazole system can be potentially dangerous. Stoichiometry, fragmentation, and stability of forming complexes were studied with tandem mass spectrometry. The Cu2+/Cu+ terconazole system was measured within the pH range of 4.0-7.2, with a concentration ratio of CuCl2 and terconazole 1:5 to 20:1, with water and ethanol as solvents (1:1). The achieved results suggest that terconazole is partially oxidized in the Cu2+/terconazole system and that this oxidation depends on the pH of a solution. Apart from the oxidized and protonated terconazole, other detected ions and complexes were not significantly affected by pH. The detection of complexes containing Cu+ is alarming because this could correspond to the occurrence of a Fenton-like reaction.

Název v anglickém jazyce

Interactions of triazole terconazole with copper and zinc cations

Popis výsledku anglicky

Terconazole is one of the triazole derivatives with an antifungal effect. It is used locally to treat vaginal yeast infections. Terconazole could interact with copper cations in the vagina or uterus of women who use an intrauterine device releasing copper cations. Other triazole derivatives in complexes with copper cations differ in their properties like toxicity or mobility. Cu2+ can be reduced in the presence of triazoles, which can lead to a Fenton-like reaction and the production of free radicals. Thus, the Cu2+/Cu+ terconazole system can be potentially dangerous. Stoichiometry, fragmentation, and stability of forming complexes were studied with tandem mass spectrometry. The Cu2+/Cu+ terconazole system was measured within the pH range of 4.0-7.2, with a concentration ratio of CuCl2 and terconazole 1:5 to 20:1, with water and ethanol as solvents (1:1). The achieved results suggest that terconazole is partially oxidized in the Cu2+/terconazole system and that this oxidation depends on the pH of a solution. Apart from the oxidized and protonated terconazole, other detected ions and complexes were not significantly affected by pH. The detection of complexes containing Cu+ is alarming because this could correspond to the occurrence of a Fenton-like reaction.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Monatshefte für Chemie - Chemical Monthly

ISSN

0026-9247

e-ISSN

1434-4475

Svazek periodika

154

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

11

Strana od-do

1071-1081

Kód UT WoS článku

001004172100002

EID výsledku v databázi Scopus

2-s2.0-85161470138