Understanding the role of nuclear lamina during the murine polyomavirus infection using microscopy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10466072" target="_blank" >RIV/00216208:11310/23:10466072 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.mcgill.ca/gci/montreal-dna-tumour-virus-meeting-dnatv" target="_blank" >https://www.mcgill.ca/gci/montreal-dna-tumour-virus-meeting-dnatv</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Understanding the role of nuclear lamina during the murine polyomavirus infection using microscopy

Popis výsledku v původním jazyce

The nuclear lamina (NL) is a dense meshwork of intermediate filaments V, type A lamins (lamin A/C), type B lamins (lamin B1 and B2) and membrane associated proteins. NL is located closely adjacent to the nucleoplasmic side of the inner nuclear membrane. It maintains the shape and integrity of the nucleus and plays important role in fine-tuning of DNA related processes e.g., replication and transcription and has been suggested to play a role in cell defense against pathogens. For viruses replicating in the nucleus, NL represents a natural barrier that restricts translocation of their genomes to the nucleus during entry or prevents virus progeny exit from the nucleus late times post-infection. Viruses had evolved different mechanisms to overcome this obstacle by affecting NL integrity or its composition. We followed a possible role of NL in the murine polyomavirus infection (MPyV).

Název v anglickém jazyce

Understanding the role of nuclear lamina during the murine polyomavirus infection using microscopy

Popis výsledku anglicky

The nuclear lamina (NL) is a dense meshwork of intermediate filaments V, type A lamins (lamin A/C), type B lamins (lamin B1 and B2) and membrane associated proteins. NL is located closely adjacent to the nucleoplasmic side of the inner nuclear membrane. It maintains the shape and integrity of the nucleus and plays important role in fine-tuning of DNA related processes e.g., replication and transcription and has been suggested to play a role in cell defense against pathogens. For viruses replicating in the nucleus, NL represents a natural barrier that restricts translocation of their genomes to the nucleus during entry or prevents virus progeny exit from the nucleus late times post-infection. Viruses had evolved different mechanisms to overcome this obstacle by affecting NL integrity or its composition. We followed a possible role of NL in the murine polyomavirus infection (MPyV).

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10607 - Virology

Projekt

<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů