DNA from BK polyomavirus is sensed during infection of reservoir cells via cGAS-STING pathway

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10479610" target="_blank" >RIV/00216208:11310/24:10479610 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.toll2024.org/abstract-e-book/" target="_blank" >https://www.toll2024.org/abstract-e-book/</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

DNA from BK polyomavirus is sensed during infection of reservoir cells via cGAS-STING pathway

Popis výsledku v původním jazyce

Human polyomaviruses (HPyVs) include 14 species that cause primary asymptomatic infections after which the virus persists in the host by a mechanism that is not well understood. Reactivation of the infection in immunosuppressed patients leads to severe disease. Recently, it has been suggested that moderate innate immune responses in reservoir cells contribute to viral persistence. For BK polyomavirus (BKPyV), cells from the urinary tract are thought to act as viral reservoirs.Here, we investigated the potential role of the cGAS-STING signalling pathway in the interferon (IFN) responses launched by primary microvascular endothelial cells from bladder (HMVECs bd) in response to BKPyV infection.

Název v anglickém jazyce

DNA from BK polyomavirus is sensed during infection of reservoir cells via cGAS-STING pathway

Popis výsledku anglicky

Human polyomaviruses (HPyVs) include 14 species that cause primary asymptomatic infections after which the virus persists in the host by a mechanism that is not well understood. Reactivation of the infection in immunosuppressed patients leads to severe disease. Recently, it has been suggested that moderate innate immune responses in reservoir cells contribute to viral persistence. For BK polyomavirus (BKPyV), cells from the urinary tract are thought to act as viral reservoirs.Here, we investigated the potential role of the cGAS-STING signalling pathway in the interferon (IFN) responses launched by primary microvascular endothelial cells from bladder (HMVECs bd) in response to BKPyV infection.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10607 - Virology

Projekt

<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů