Cobalt-ferrite nano-cubes for magnetic hyperthermia applications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10481125" target="_blank" >RIV/00216208:11310/24:10481125 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JUXaBuokAl" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JUXaBuokAl</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jallcom.2024.174415" target="_blank" >10.1016/j.jallcom.2024.174415</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cobalt-ferrite nano-cubes for magnetic hyperthermia applications

Popis výsledku v původním jazyce

Highly crystalline superparamagnetic nano-cubes of CoFe2O4 with size of about 15 nm were prepared by the thermal decomposition method. The structure, morphology, magnetic properties, magnetothermal response, and cytotoxicity study were used to investigate the CoFe2O4 nano-cubes for magnetic hyperthermia. Diffraction methods (employing X-ray and transition electron microscope) confirm the presence of an inverted spinel structure of cobalt ferrite. The presence of a spin-disordered magnetically dead layer that has been confirmed both by X-ray diffraction and magnetometry data. The average crystallite size D(XRD) ~ 12 nm has been found smaller than the average physical edge of the nano-cube observed by transition electron microscope D(TEM) ~ 15 nm. The analysis of the isothermal magnetization data by assuming a cubic instead of spherical shape of the prepared nanoparticles yielded conclusive values of relevant parameters. The effective magnetocrystalline anisotropy constant K = 2.3x10(5) J/m3 determined by the Law of approach and by the fitting of coercivity data is in excellent correspondence with collected zero-field cooled magnetization data for nano-cube system of crystallite size ~ 12 nm. In-vitro cytotoxicity tests on U87MG (cancer model) and HDF (non-cancer models) confirm the good biocompatibility and very low cytotoxicity. One of the our mail contributions is, that we provide exact analysis of relaxation processes responsible for heat generation in our nano-cube system and we obtained higher SAR and IPL coefficients than 30 commercial iron-oxide nanoparticle systems designed for magnetic hyperthermia. This, along with the promising results of the magneto-thermal response, indicates the suitability of using the prepared nano-cubes for applications in magnetic particle hyperthermia.

Název v anglickém jazyce

Cobalt-ferrite nano-cubes for magnetic hyperthermia applications

Popis výsledku anglicky

Highly crystalline superparamagnetic nano-cubes of CoFe2O4 with size of about 15 nm were prepared by the thermal decomposition method. The structure, morphology, magnetic properties, magnetothermal response, and cytotoxicity study were used to investigate the CoFe2O4 nano-cubes for magnetic hyperthermia. Diffraction methods (employing X-ray and transition electron microscope) confirm the presence of an inverted spinel structure of cobalt ferrite. The presence of a spin-disordered magnetically dead layer that has been confirmed both by X-ray diffraction and magnetometry data. The average crystallite size D(XRD) ~ 12 nm has been found smaller than the average physical edge of the nano-cube observed by transition electron microscope D(TEM) ~ 15 nm. The analysis of the isothermal magnetization data by assuming a cubic instead of spherical shape of the prepared nanoparticles yielded conclusive values of relevant parameters. The effective magnetocrystalline anisotropy constant K = 2.3x10(5) J/m3 determined by the Law of approach and by the fitting of coercivity data is in excellent correspondence with collected zero-field cooled magnetization data for nano-cube system of crystallite size ~ 12 nm. In-vitro cytotoxicity tests on U87MG (cancer model) and HDF (non-cancer models) confirm the good biocompatibility and very low cytotoxicity. One of the our mail contributions is, that we provide exact analysis of relaxation processes responsible for heat generation in our nano-cube system and we obtained higher SAR and IPL coefficients than 30 commercial iron-oxide nanoparticle systems designed for magnetic hyperthermia. This, along with the promising results of the magneto-thermal response, indicates the suitability of using the prepared nano-cubes for applications in magnetic particle hyperthermia.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Alloys and Compounds

ISSN

0925-8388

e-ISSN

1873-4669

Svazek periodika

989

Číslo periodika v rámci svazku

June

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

14

Strana od-do

174415

Kód UT WoS článku

001224886800001

EID výsledku v databázi Scopus

2-s2.0-85189686763