Subclinical peripheral inflammation has systemic effects impacting central nervous system proteome in budgerigars
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10483099" target="_blank" >RIV/00216208:11310/24:10483099 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11110/24:10483099
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=.C3Dqq.yk-" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=.C3Dqq.yk-</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.dci.2024.105213" target="_blank" >10.1016/j.dci.2024.105213</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Subclinical peripheral inflammation has systemic effects impacting central nervous system proteome in budgerigars
Popis výsledku v původním jazyce
Regulation of neuroimmune interactions varies across avian species. Little is presently known about the interplay between periphery and central nervous system (CNS) in parrots, birds sensitive to neuroinflammation. Here we investigated the systemic and CNS responses to dextran sulphate sodium (DSS)- and lipopolysaccharide (LPS)induced subclinical acute peripheral inflammation in budgerigar ( Melopsittacus undulatus ). Three experimental treatment groups differing in DSS and LPS stimulation were compared to controls. Individuals treated with DSS showed significant histological intestinal damage. Through quantitative proteomics we described changes in plasma (PL) and cerebrospinal fluid (CSF) composition. In total, we identified 180 proteins in PL and 978 proteins in CSF, with moderate co -structure between the proteomes. Between treatments we detected differences in immune, coagulation and metabolic pathways. Proteomic variation was associated with the levels of proinflammatory cytokine mRNA expression in intestine and brain. Our findings shed light on systemic impacts of peripheral low-grade inflammation in birds.
Název v anglickém jazyce
Subclinical peripheral inflammation has systemic effects impacting central nervous system proteome in budgerigars
Popis výsledku anglicky
Regulation of neuroimmune interactions varies across avian species. Little is presently known about the interplay between periphery and central nervous system (CNS) in parrots, birds sensitive to neuroinflammation. Here we investigated the systemic and CNS responses to dextran sulphate sodium (DSS)- and lipopolysaccharide (LPS)induced subclinical acute peripheral inflammation in budgerigar ( Melopsittacus undulatus ). Three experimental treatment groups differing in DSS and LPS stimulation were compared to controls. Individuals treated with DSS showed significant histological intestinal damage. Through quantitative proteomics we described changes in plasma (PL) and cerebrospinal fluid (CSF) composition. In total, we identified 180 proteins in PL and 978 proteins in CSF, with moderate co -structure between the proteomes. Between treatments we detected differences in immune, coagulation and metabolic pathways. Proteomic variation was associated with the levels of proinflammatory cytokine mRNA expression in intestine and brain. Our findings shed light on systemic impacts of peripheral low-grade inflammation in birds.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10613 - Zoology
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2024
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Developmental and Comparative Immunology
ISSN
0145-305X
e-ISSN
1879-0089
Svazek periodika
159
Číslo periodika v rámci svazku
October
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
15
Strana od-do
105213
Kód UT WoS článku
001258278300001
EID výsledku v databázi Scopus
2-s2.0-85195886866