miRNA146a is a key component of immunnosupressive environment of hepatocytes chronically infected with HBV

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10486090" target="_blank" >RIV/00216208:11310/24:10486090 - isvavai.cz</a>
Výsledek na webu
—
DOI - Digital Object Identifier
—

Jazyk výsledku
angličtina
Název v původním jazyce
miRNA146a is a key component of immunnosupressive environment of hepatocytes chronically infected with HBV
Popis výsledku v původním jazyce
Hepatitis B virus (HBV) causes acute hepatitis and can lead to chronic liver inflammation, often resulting in hepatocellular carcinoma. Known as a stealth virus, virus," HBV can evade recognition by the immune system. Plasmacytoid dendritic cells (pDCs), robust producers of type I and III interferons (IFNs), 1 which are crucial for HBV clearance. However, miRNA146a, an immunosuppressive and proliferative miRNA in hepatocytes, modulates pDCs by silencing TRAF6 and IRAK1/4 proteins.
Název v anglickém jazyce
miRNA146a is a key component of immunnosupressive environment of hepatocytes chronically infected with HBV
Popis výsledku anglicky
Hepatitis B virus (HBV) causes acute hepatitis and can lead to chronic liver inflammation, often resulting in hepatocellular carcinoma. Known as a stealth virus, virus," HBV can evade recognition by the immune system. Plasmacytoid dendritic cells (pDCs), robust producers of type I and III interferons (IFNs), 1 which are crucial for HBV clearance. However, miRNA146a, an immunosuppressive and proliferative miRNA in hepatocytes, modulates pDCs by silencing TRAF6 and IRAK1/4 proteins.

Projekt
<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění
2024
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Podobné výsledky(10)