Investigation of BKPyV life cycle, activation of innate immune responses and membrane remodeling in microvascular endothelial cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10486112" target="_blank" >RIV/00216208:11310/24:10486112 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Investigation of BKPyV life cycle, activation of innate immune responses and membrane remodeling in microvascular endothelial cells

Popis výsledku v původním jazyce

Polyomaviruses (PyVs) are small double-stranded DNA viruses that occur widely in nature. Among the 14 known human PyVs, three are particularly relevant: BK Polyomavirus (BKPyV), JC polyomavirus, and Merkel cell carcinoma Polyomavirus. BKPyV, with a global prevalence of approximately 80% in adults, typically causes asymptomatic primary infection. After initial infection, it disseminates via the bloodstream and establishes persistence in the urinary tract. Reactivation of BKPyV can occur in immunocompromised patients, leading to complications such as nephritis or graft loss1-2. Unfortunately, there are currently no specific antiviral treatments available for BKPyV infection.

Název v anglickém jazyce

Investigation of BKPyV life cycle, activation of innate immune responses and membrane remodeling in microvascular endothelial cells

Popis výsledku anglicky

Polyomaviruses (PyVs) are small double-stranded DNA viruses that occur widely in nature. Among the 14 known human PyVs, three are particularly relevant: BK Polyomavirus (BKPyV), JC polyomavirus, and Merkel cell carcinoma Polyomavirus. BKPyV, with a global prevalence of approximately 80% in adults, typically causes asymptomatic primary infection. After initial infection, it disseminates via the bloodstream and establishes persistence in the urinary tract. Reactivation of BKPyV can occur in immunocompromised patients, leading to complications such as nephritis or graft loss1-2. Unfortunately, there are currently no specific antiviral treatments available for BKPyV infection.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10607 - Virology

Projekt

<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů