Transmembrane formins as active cargoes of membrane trafficking

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10487749" target="_blank" >RIV/00216208:11310/24:10487749 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ux8vdFSEbC" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ux8vdFSEbC</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/jxb/erae078" target="_blank" >10.1093/jxb/erae078</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Transmembrane formins as active cargoes of membrane trafficking

Popis výsledku v původním jazyce

Formins are a large, evolutionarily old family of cytoskeletal regulators whose roles include actin capping and nucleation, as well as modulation of microtubule dynamics. The plant class I formin clade is characterized by a unique domain organization, as most of its members are transmembrane proteins with possible cell wall-binding motifs exposed to the extracytoplasmic space-a structure that appears to be a synapomorphy of the plant kingdom. While such transmembrane formins are traditionally considered mainly as plasmalemma-localized proteins contributing to the organization of the cell cortex, we review, from a cell biology perspective, the growing evidence that they can also, at least temporarily, reside (and in some cases also function) in endomembranes including secretory and endocytotic pathway compartments, the endoplasmic reticulum, the nuclear envelope, and the tonoplast. Based on this evidence, we propose that class I formins may thus serve as &apos;active cargoes&apos; of membrane trafficking-membrane-embedded proteins that modulate the fate of endo- or exocytotic compartments while being transported by them. Transmembrane class I formins are cytoskeletal regulators localizing to the plasmalemma and endomembranes that may act as &apos;active cargoes&apos; of membrane trafficking, modulating the fate of membrane compartments carrying them.

Název v anglickém jazyce

Transmembrane formins as active cargoes of membrane trafficking

Popis výsledku anglicky

Formins are a large, evolutionarily old family of cytoskeletal regulators whose roles include actin capping and nucleation, as well as modulation of microtubule dynamics. The plant class I formin clade is characterized by a unique domain organization, as most of its members are transmembrane proteins with possible cell wall-binding motifs exposed to the extracytoplasmic space-a structure that appears to be a synapomorphy of the plant kingdom. While such transmembrane formins are traditionally considered mainly as plasmalemma-localized proteins contributing to the organization of the cell cortex, we review, from a cell biology perspective, the growing evidence that they can also, at least temporarily, reside (and in some cases also function) in endomembranes including secretory and endocytotic pathway compartments, the endoplasmic reticulum, the nuclear envelope, and the tonoplast. Based on this evidence, we propose that class I formins may thus serve as &apos;active cargoes&apos; of membrane trafficking-membrane-embedded proteins that modulate the fate of endo- or exocytotic compartments while being transported by them. Transmembrane class I formins are cytoskeletal regulators localizing to the plasmalemma and endomembranes that may act as &apos;active cargoes&apos; of membrane trafficking, modulating the fate of membrane compartments carrying them.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10611 - Plant sciences, botany

Projekt

<a href="/cs/project/GA22-33471S" target="_blank" >GA22-33471S: Forminy třídy I v propojení dynamiky membrán a cytoskeletu při vývoji kořene</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Experimental Botany

ISSN

0022-0957

e-ISSN

1460-2431

Svazek periodika

75

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

17

Strana od-do

3668-3684

Kód UT WoS článku

001185686700001

EID výsledku v databázi Scopus

2-s2.0-85196908719