Editorial: Fertilization and early embryogenesis: from research to clinical practice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F25%3A10494874" target="_blank" >RIV/00216208:11310/25:10494874 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=EiKetOkyc7" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=EiKetOkyc7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fcell.2024.1547205" target="_blank" >10.3389/fcell.2024.1547205</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Editorial: Fertilization and early embryogenesis: from research to clinical practice

Popis výsledku v původním jazyce

The fusion of an egg and a sperm triggers a complex plethora of events that will ultimately lead to the formation of a new individual. Embryonic development requires the precise orchestration of a formidable number of events. Although our knowledge of the underlying mechanisms involved has significantly increased over the last 2 decades, new discoveries continue to surprise us, further underlining the complexity and diversity of ontogenesis in different species. The intricacy of events that occur during early development, with the rapid changes in cellular morphology and behavior, may serve as an explanation for the frequent failure of mammalian embryos. This Research Topic, &quot;Fertilization and early embryogenesis: from Research to clinical practice,&quot; is comprised of thirteen publications that cover the complexity of germ cell, embryonic, and fetal development in a diverse number of species, including mice, cattle, pigs, humans, Xenopus, and axolotls. The Research Topic of these papers range from basic research on animal germ cells and embryos to clinical studies on human IVF embryos to placentation and postimplantation events.Five studies focused on chromosomal and epigenetic aspects of early development. These include retrospective and clinical studies in humans. In Sanovec et al., the authors identified a potential new link between chromatin defects and disturbed mobility in sperm.The interaction between the DNA packaging protein protamine 2, nuclear envelope component lamin B2/3, and the cytoskeletal protein septin 12, provide a mechanistical link between abnormal sperm chromatin condensation and altered motility in a mouse model. The authors further provided evidence that a similar connection exists in human sperm. For instance, the altered expression and localization of homologue proteins is associated with low sperm motility known as asthenozoospermia.

Název v anglickém jazyce

Editorial: Fertilization and early embryogenesis: from research to clinical practice

Popis výsledku anglicky

The fusion of an egg and a sperm triggers a complex plethora of events that will ultimately lead to the formation of a new individual. Embryonic development requires the precise orchestration of a formidable number of events. Although our knowledge of the underlying mechanisms involved has significantly increased over the last 2 decades, new discoveries continue to surprise us, further underlining the complexity and diversity of ontogenesis in different species. The intricacy of events that occur during early development, with the rapid changes in cellular morphology and behavior, may serve as an explanation for the frequent failure of mammalian embryos. This Research Topic, &quot;Fertilization and early embryogenesis: from Research to clinical practice,&quot; is comprised of thirteen publications that cover the complexity of germ cell, embryonic, and fetal development in a diverse number of species, including mice, cattle, pigs, humans, Xenopus, and axolotls. The Research Topic of these papers range from basic research on animal germ cells and embryos to clinical studies on human IVF embryos to placentation and postimplantation events.Five studies focused on chromosomal and epigenetic aspects of early development. These include retrospective and clinical studies in humans. In Sanovec et al., the authors identified a potential new link between chromatin defects and disturbed mobility in sperm.The interaction between the DNA packaging protein protamine 2, nuclear envelope component lamin B2/3, and the cytoskeletal protein septin 12, provide a mechanistical link between abnormal sperm chromatin condensation and altered motility in a mouse model. The authors further provided evidence that a similar connection exists in human sperm. For instance, the altered expression and localization of homologue proteins is associated with low sperm motility known as asthenozoospermia.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

10605 - Developmental biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů