Enantioselective Desymmetrization by Chiral Bifunctional H-Bonding Organocatalysts

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F25%3A10513947" target="_blank" >RIV/00216208:11310/25:10513947 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=F2gUJ8.m6l" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=F2gUJ8.m6l</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/chem.202502172" target="_blank" >10.1002/chem.202502172</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Enantioselective Desymmetrization by Chiral Bifunctional H-Bonding Organocatalysts

Popis výsledku v původním jazyce

Enantioselective desymmetrization has emerged as an effective method for generating highly enriched chiral molecules from achiral compounds. In recent years, organocatalysis has played an increasingly prominent role in this field, offering metal-free and environmentally benign alternatives to traditional asymmetric catalysis. This review focuses on organocatalytic approaches in desymmetrization reactions that utilize bifunctional hydrogen activation of the substrate by a chiral organocatalyst. The most common types of chiral bifunctional organocatalysts include cinchona alkaloids and their derivatives, such as thioureas, sulfonamides, and squaramides. The following text provides an overview of the enantioselective desymmetrization methods that have been described to date for meso-anhydrides, meso-diols, amines, small heterocyclic rings, and various carbonyl compound derivatives.

Název v anglickém jazyce

Enantioselective Desymmetrization by Chiral Bifunctional H-Bonding Organocatalysts

Popis výsledku anglicky

Enantioselective desymmetrization has emerged as an effective method for generating highly enriched chiral molecules from achiral compounds. In recent years, organocatalysis has played an increasingly prominent role in this field, offering metal-free and environmentally benign alternatives to traditional asymmetric catalysis. This review focuses on organocatalytic approaches in desymmetrization reactions that utilize bifunctional hydrogen activation of the substrate by a chiral organocatalyst. The most common types of chiral bifunctional organocatalysts include cinchona alkaloids and their derivatives, such as thioureas, sulfonamides, and squaramides. The following text provides an overview of the enantioselective desymmetrization methods that have been described to date for meso-anhydrides, meso-diols, amines, small heterocyclic rings, and various carbonyl compound derivatives.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

<a href="/cs/project/GA24-12575S" target="_blank" >GA24-12575S: Přenos chirality pomocí organokatalýzy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemistry - A European Journal

ISSN

0947-6539

e-ISSN

1521-3765

Svazek periodika

31

Číslo periodika v rámci svazku

61

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

22

Strana od-do

e02172

Kód UT WoS článku

001588633400001

EID výsledku v databázi Scopus

2-s2.0-105018010910