Self-Assembling Behavior of Cysteine-Modified Oligopeptides: An XPS and NEXAFS Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F18%3A10425347" target="_blank" >RIV/00216208:11320/18:10425347 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3UU4kngM_8" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3UU4kngM_8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.jpcc.8b00794" target="_blank" >10.1021/acs.jpcc.8b00794</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Self-Assembling Behavior of Cysteine-Modified Oligopeptides: An XPS and NEXAFS Study

Popis výsledku v původním jazyce

Achieving rigorous control over the procedures aiming at modifying surfaces by selective and covalent anchoring of bioactive molecules is a mandatory step in view of the realistic applicability of bioengineered materials in the field of tissue engineering, biosensing, and nanomedicine. In this context, we report here a proof-of-concept study carried out on a self-assembling peptide (SAP) functionalized with cysteine (Cys), as to ideally grant molecule grafting to gold surfaces. The effectiveness of the surface functionalization in a monolayer regime and the molecular stability of SAP-Cys were probed by X-ray photoelectron spectroscopy; the highly ordered self-organization attained by the grafting molecules was assessed by means of angular-dependent near edge X-ray absorption spectroscopy studies. This study opens wide perspectives for efficient chemical modification of surfaces with biomolecules to include bioactive motifs and/or to add nanometric fibrous patterns.

Název v anglickém jazyce

Self-Assembling Behavior of Cysteine-Modified Oligopeptides: An XPS and NEXAFS Study

Popis výsledku anglicky

Achieving rigorous control over the procedures aiming at modifying surfaces by selective and covalent anchoring of bioactive molecules is a mandatory step in view of the realistic applicability of bioengineered materials in the field of tissue engineering, biosensing, and nanomedicine. In this context, we report here a proof-of-concept study carried out on a self-assembling peptide (SAP) functionalized with cysteine (Cys), as to ideally grant molecule grafting to gold surfaces. The effectiveness of the surface functionalization in a monolayer regime and the molecular stability of SAP-Cys were probed by X-ray photoelectron spectroscopy; the highly ordered self-organization attained by the grafting molecules was assessed by means of angular-dependent near edge X-ray absorption spectroscopy studies. This study opens wide perspectives for efficient chemical modification of surfaces with biomolecules to include bioactive motifs and/or to add nanometric fibrous patterns.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10305 - Fluids and plasma physics (including surface physics)

Projekt

—

Návaznosti

—

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Physical Chemistry C

ISSN

1932-7447

e-ISSN

—

Svazek periodika

122

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

6236-6239

Kód UT WoS článku

000428356700044

EID výsledku v databázi Scopus

2-s2.0-85044371135