Ultrasonic Formation of Copper/Iron Graphene Oxide for Ketorolac Delivery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F19%3A10405970" target="_blank" >RIV/00216208:11320/19:10405970 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=99ptnfvQco" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=99ptnfvQco</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1142/S0219581X19400726" target="_blank" >10.1142/S0219581X19400726</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ultrasonic Formation of Copper/Iron Graphene Oxide for Ketorolac Delivery

Popis výsledku v původním jazyce

New accessible sonochemical methods were developed for the functionalization of synthesized graphene oxide (GO) with copper/iron compounds and drug intercalation into their structure in aqueous solution at ambient conditions by using ultrasound (20 kHz) treatment. The sonochemical formation mechanism of a new nanomaterial was revealed through the structural analysis of three types of nanocomposites: (i) copper@graphene oxide, (ii) copper/iron@graphene oxide and (iii) iron@graphene oxide. Unique copper/iron-modified graphene oxide nanocomposites can be used as nanocarriers for the anti-inflammatory drug (ketorolac) delivery in aqueous solution due to the reduced submicron size and enlarged surface area. Disintegration of the ultrasonically intercalated ketorolac followed the exponential decay curve fit at higher pH values of the aqueous solution with a higher decay constant observed in copper/iron-modified graphene oxide nanocomposites.

Název v anglickém jazyce

Ultrasonic Formation of Copper/Iron Graphene Oxide for Ketorolac Delivery

Popis výsledku anglicky

New accessible sonochemical methods were developed for the functionalization of synthesized graphene oxide (GO) with copper/iron compounds and drug intercalation into their structure in aqueous solution at ambient conditions by using ultrasound (20 kHz) treatment. The sonochemical formation mechanism of a new nanomaterial was revealed through the structural analysis of three types of nanocomposites: (i) copper@graphene oxide, (ii) copper/iron@graphene oxide and (iii) iron@graphene oxide. Unique copper/iron-modified graphene oxide nanocomposites can be used as nanocarriers for the anti-inflammatory drug (ketorolac) delivery in aqueous solution due to the reduced submicron size and enlarged surface area. Disintegration of the ultrasonically intercalated ketorolac followed the exponential decay curve fit at higher pH values of the aqueous solution with a higher decay constant observed in copper/iron-modified graphene oxide nanocomposites.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10305 - Fluids and plasma physics (including surface physics)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Nanoscience

ISSN

0219-581X

e-ISSN

—

Svazek periodika

18

Číslo periodika v rámci svazku

3-4

Stát vydavatele periodika

SG - Singapurská republika

Počet stran výsledku

4

Strana od-do

1940072

Kód UT WoS článku

000472775200073

EID výsledku v databázi Scopus

2-s2.0-85068181153