Mitochondrial membrane model: Lipids, elastic properties, and the changing curvature of cardiolipin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F23%3A10474639" target="_blank" >RIV/00216208:11320/23:10474639 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=s4J_lt~eYl" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=s4J_lt~eYl</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bpj.2023.10.002" target="_blank" >10.1016/j.bpj.2023.10.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mitochondrial membrane model: Lipids, elastic properties, and the changing curvature of cardiolipin

Popis výsledku v původním jazyce

Mammalian and Drosophila melanogaster model mitochondrial membrane compositions are constructed from experimental data. Simplified compositions for inner and outer mitochondrial membranes are provided, including an asymmetric inner mitochondrial membrane. We performed atomistic molecular dynamics simulations of these membranes and computed their material properties. When comparing these properties to those obtained by extrapolation from their constituting lipids, we find good overall agreement. Finally, we analyzed the curvature effect of cardiolipin, considering ion concentration effects, oxidation, and pH. We draw the conclusion that cardiolipin-negative curvature is most likely due to counterion effects, such as cation adsorption, in particular of H3O thorn . This oft-neglected effect might account for the puzzling behavior of this lipid.

Název v anglickém jazyce

Mitochondrial membrane model: Lipids, elastic properties, and the changing curvature of cardiolipin

Popis výsledku anglicky

Mammalian and Drosophila melanogaster model mitochondrial membrane compositions are constructed from experimental data. Simplified compositions for inner and outer mitochondrial membranes are provided, including an asymmetric inner mitochondrial membrane. We performed atomistic molecular dynamics simulations of these membranes and computed their material properties. When comparing these properties to those obtained by extrapolation from their constituting lipids, we find good overall agreement. Finally, we analyzed the curvature effect of cardiolipin, considering ion concentration effects, oxidation, and pH. We draw the conclusion that cardiolipin-negative curvature is most likely due to counterion effects, such as cation adsorption, in particular of H3O thorn . This oft-neglected effect might account for the puzzling behavior of this lipid.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10102 - Applied mathematics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biophysical Journal

ISSN

0006-3495

e-ISSN

1542-0086

Svazek periodika

122

Číslo periodika v rámci svazku

21

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

4274-4287

Kód UT WoS článku

001108963200001

EID výsledku v databázi Scopus

2-s2.0-85174457874