Alternating partially quaternized polytriazole amphiphiles: bridging neutral and ionic domains for tunable aggregation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F25%3A10510603" target="_blank" >RIV/00216208:11320/25:10510603 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9tSwNmT2cE" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9tSwNmT2cE</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/d5tb01774b" target="_blank" >10.1039/d5tb01774b</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Alternating partially quaternized polytriazole amphiphiles: bridging neutral and ionic domains for tunable aggregation

Popis výsledku v původním jazyce

Poly(1,2,3-triazole)-based polymers remain underexplored as a versatile platform for biomedical soft materials. Here, we report the modular synthesis of amphiphilic poly(1,2,3-triazole)-co-polytriazolium copolymers (qH-PETH) via copper(i)-catalyzed azide-alkyne cycloaddition (CuAAC) polyaddition and post-polymerization quaternization with a degree of quaternization equal to (0.85). These polymers exhibit unusual visible colouration in the absence of chromophores-appearing almost colourless in N-methyl-2-pyrrolidone (NMP), orange in DMSO, and pale orange in water-accompanied by a pronounced red shift in non-polar solvents such as dichloromethane (DCM) or chloroform. This optical behaviour is attributed to solvent-dependent supramolecular aggregation. Dynamic light scattering (DLS) measurements reveal hydrodynamic diameters of &lt;20 nm in water and approximately 500 nm in chloroform for quaternized polymers (qH-PETH), indicating strong aggregation in low-polarity environments. UV-vis spectroscopy and atomic force microscopy (AFM) further support aggregation-induced optical effects modulated by solvent polarity and hydrogen-bonding capacity. Both neutral and quaternized polymers display excellent cytocompatibility toward human cell lines (HeLa, HEK293, THP-1) at concentrations up to 100 mu g mL(-1), with no detectable immunogenic activation. These findings position poly(1,2,3-triazole)-co-polytriazolium copolymers as a promising, tunable class of biocompatible soft materials for biointerface engineering and responsive biomedical applications.

Název v anglickém jazyce

Alternating partially quaternized polytriazole amphiphiles: bridging neutral and ionic domains for tunable aggregation

Popis výsledku anglicky

Poly(1,2,3-triazole)-based polymers remain underexplored as a versatile platform for biomedical soft materials. Here, we report the modular synthesis of amphiphilic poly(1,2,3-triazole)-co-polytriazolium copolymers (qH-PETH) via copper(i)-catalyzed azide-alkyne cycloaddition (CuAAC) polyaddition and post-polymerization quaternization with a degree of quaternization equal to (0.85). These polymers exhibit unusual visible colouration in the absence of chromophores-appearing almost colourless in N-methyl-2-pyrrolidone (NMP), orange in DMSO, and pale orange in water-accompanied by a pronounced red shift in non-polar solvents such as dichloromethane (DCM) or chloroform. This optical behaviour is attributed to solvent-dependent supramolecular aggregation. Dynamic light scattering (DLS) measurements reveal hydrodynamic diameters of &lt;20 nm in water and approximately 500 nm in chloroform for quaternized polymers (qH-PETH), indicating strong aggregation in low-polarity environments. UV-vis spectroscopy and atomic force microscopy (AFM) further support aggregation-induced optical effects modulated by solvent polarity and hydrogen-bonding capacity. Both neutral and quaternized polymers display excellent cytocompatibility toward human cell lines (HeLa, HEK293, THP-1) at concentrations up to 100 mu g mL(-1), with no detectable immunogenic activation. These findings position poly(1,2,3-triazole)-co-polytriazolium copolymers as a promising, tunable class of biocompatible soft materials for biointerface engineering and responsive biomedical applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10305 - Fluids and plasma physics (including surface physics)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Materials Chemistry B

ISSN

2050-750X

e-ISSN

2050-7518

Svazek periodika

13

Číslo periodika v rámci svazku

40

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

12895-12902

Kód UT WoS článku

001585868600001

EID výsledku v databázi Scopus

2-s2.0-105018679886