Whole-Brain Dimensions of Intrinsic Connectivity Capture Modality-Specific and Heteromodal Language Representations

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F26%3ABJKT29HK" target="_blank" >RIV/00216208:11320/26:BJKT29HK - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1523/JNEUROSCI.1876-24.2025" target="_blank" >http://dx.doi.org/10.1523/JNEUROSCI.1876-24.2025</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1523/JNEUROSCI.1876-24.2025" target="_blank" >10.1523/JNEUROSCI.1876-24.2025</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Whole-Brain Dimensions of Intrinsic Connectivity Capture Modality-Specific and Heteromodal Language Representations

Popis výsledku v původním jazyce

Comprehension of spoken and written language involves a hierarchical sequence of modality-specific and heteromodal processes. While these have been localized to different regions, modality-selective responses extend beyond them, implicating large-scale network organization in language comprehension. Dimensions of whole-brain connectivity, derived from intrinsic activity, have been proposed as a general organizing framework for cognition. Here, we test their utility in accounting for the spatial distribution of task-evoked activity during language comprehension. We investigated brain activity in human males and females in response to psycholinguistic variables linked to input processing and meaning in a sentence comprehension task presented both visually and auditorily. Macroscale patterns of brain activity were similar across modalities for sentence-level and semantic variables, but effects of orthographic and phonological distance were negatively correlated between modalities. The first dimension, separating heteromodal and unimodal cortices, showed no differences across modalities for sentence processing and semantic variables and opposite effects of word length and orthographic/phonological distance for spoken and written words, supporting the notion that higher-order processing requires heteromodal resources different to those linked to input processing. The second dimension, separating auditory–motor and visual processes, showed an asymmetry in the recruitment of the unimodal systems—listening to long and semantically dissimilar words involved stronger recruitment of primary auditory–motor regions and low visual engagement. These findings show that the language system is organized according to large-scale axes of intrinsic connectivity, with psycholinguistic processes varying systematically along whole-brain dimensions. This supports the view that language comprehension reflects general principles of cortical organization. Copyright © 2025 Marin-Marin et al.

Název v anglickém jazyce

Whole-Brain Dimensions of Intrinsic Connectivity Capture Modality-Specific and Heteromodal Language Representations

Popis výsledku anglicky

Comprehension of spoken and written language involves a hierarchical sequence of modality-specific and heteromodal processes. While these have been localized to different regions, modality-selective responses extend beyond them, implicating large-scale network organization in language comprehension. Dimensions of whole-brain connectivity, derived from intrinsic activity, have been proposed as a general organizing framework for cognition. Here, we test their utility in accounting for the spatial distribution of task-evoked activity during language comprehension. We investigated brain activity in human males and females in response to psycholinguistic variables linked to input processing and meaning in a sentence comprehension task presented both visually and auditorily. Macroscale patterns of brain activity were similar across modalities for sentence-level and semantic variables, but effects of orthographic and phonological distance were negatively correlated between modalities. The first dimension, separating heteromodal and unimodal cortices, showed no differences across modalities for sentence processing and semantic variables and opposite effects of word length and orthographic/phonological distance for spoken and written words, supporting the notion that higher-order processing requires heteromodal resources different to those linked to input processing. The second dimension, separating auditory–motor and visual processes, showed an asymmetry in the recruitment of the unimodal systems—listening to long and semantically dissimilar words involved stronger recruitment of primary auditory–motor regions and low visual engagement. These findings show that the language system is organized according to large-scale axes of intrinsic connectivity, with psycholinguistic processes varying systematically along whole-brain dimensions. This supports the view that language comprehension reflects general principles of cortical organization. Copyright © 2025 Marin-Marin et al.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Projekt

—

Návaznosti

—

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Neuroscience

ISSN

0270-6474

e-ISSN

—

Svazek periodika

45

Číslo periodika v rámci svazku

22

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

1

Strana od-do

e1876242025

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-105006550754