Effect of Creatine Applied as Food Supplement on Human Metabolism

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11510%2F10%3A10071295" target="_blank" >RIV/00216208:11510/10:10071295 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effect of Creatine Applied as Food Supplement on Human Metabolism

Popis výsledku v původním jazyce

Creatine (CR), is recommended for application as food supplement. It is supposed that human organism uses it for formation of CR phosphate as source of energy. In our short-term experiments we have observed changes in the metabolism of two-carbon (2C) units and of thiolic substances 4 to 6 hours after CR supplementation. The level of thiodiglycolic acid (TDGA) in urine increased rapidly and then decreased again to the original level. The level of TDGA in urine is a marker of disturbance in metabolic pathways of 2C units and of thiolic compounds. Our long-term CR supplementation, revealed that the biochemical pathways, affected by CR application included intrinsic participation of vitamin B12 and folates. The levels of those two vitamins changed in a mutually reverse way. The men under study can be divided into 4 different groups according to changes of CR levels found in urine, and of levels of folates and vitamin B12, determined in blood before and after CR administration.

Název v anglickém jazyce

Effect of Creatine Applied as Food Supplement on Human Metabolism

Popis výsledku anglicky

Creatine (CR), is recommended for application as food supplement. It is supposed that human organism uses it for formation of CR phosphate as source of energy. In our short-term experiments we have observed changes in the metabolism of two-carbon (2C) units and of thiolic substances 4 to 6 hours after CR supplementation. The level of thiodiglycolic acid (TDGA) in urine increased rapidly and then decreased again to the original level. The level of TDGA in urine is a marker of disturbance in metabolic pathways of 2C units and of thiolic compounds. Our long-term CR supplementation, revealed that the biochemical pathways, affected by CR application included intrinsic participation of vitamin B12 and folates. The levels of those two vitamins changed in a mutually reverse way. The men under study can be divided into 4 different groups according to changes of CR levels found in urine, and of levels of folates and vitamin B12, determined in blood before and after CR administration.

Druh

O - Ostatní výsledky

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů