Polygenic Study of Endurance-Associated Genetic Markers NOS3 (Glu298Asp), BDKRB2 (-9/+9), UCP2 (Ala55Val), AMPD1 (Gln45Ter) and ACE (I/D) in Polish Male Half Marathoners

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11510%2F18%3A10383505" target="_blank" >RIV/00216208:11510/18:10383505 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1515/hukin-2017-0204" target="_blank" >https://doi.org/10.1515/hukin-2017-0204</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/hukin-2017-0204" target="_blank" >10.1515/hukin-2017-0204</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Polygenic Study of Endurance-Associated Genetic Markers NOS3 (Glu298Asp), BDKRB2 (-9/+9), UCP2 (Ala55Val), AMPD1 (Gln45Ter) and ACE (I/D) in Polish Male Half Marathoners

Popis výsledku v původním jazyce

The purpose of this study was to investigate individually and in combination the association between the ACE (I/D), NOS3 (Glu298Asp), BDKRB2 (-9/+ 9), UCP2 (Ala55Val) and AMPD1 (Gln45Ter) variants with endurance performance in a large, performance-homogenous cohort of elite Polish half marathoners. The study group consisted of 180 elite half marathoners: 76 with time &lt; 100 minutes and 104 with time &gt; 100 minutes. DNA of the subjects was extracted from buccal cells donated by the runners and genotyping was carried out using an allelic discrimination assay with a C1000 Touch Thermal Cycler (Bio-Rad, Germany) instrument with TaqMan (R) probes (NOS3, UCP2, and AMPD1) and a T100 (TM) Thermal Cycler (Bio-Rad, Germany) instrument (ACE and BDKRB2). We found that the UCP2 Ala55Val polymorphism was associated with running performance, with the subjects carrying the Val allele being overrepresented in the group of most successful runners (&lt; 100 min) compared to the &gt; 100 min group (84.2 vs. 55.8%; OR = 4.23, p &lt; 0.0001). Next, to assess the combined impact of 4 gene polymorphisms, all athletes were classified according to the number of &apos;endurance&apos; alleles (ACE I, NOS3 Glu, BDKRB2 -9, UCP2 Val) they possessed. The proportion of subjects with a high (4-7) number of &apos;endurance&apos; alleles was greater in the better half marathoners group compared with the &gt; 100 min group (73.7 vs. 51.9%; OR = 2.6, p = 0.0034). These data suggest that the likelihood of becoming an elite half marathoner partly depends on the carriage of a high number of endurance-related alleles.

Název v anglickém jazyce

Polygenic Study of Endurance-Associated Genetic Markers NOS3 (Glu298Asp), BDKRB2 (-9/+9), UCP2 (Ala55Val), AMPD1 (Gln45Ter) and ACE (I/D) in Polish Male Half Marathoners

Popis výsledku anglicky

The purpose of this study was to investigate individually and in combination the association between the ACE (I/D), NOS3 (Glu298Asp), BDKRB2 (-9/+ 9), UCP2 (Ala55Val) and AMPD1 (Gln45Ter) variants with endurance performance in a large, performance-homogenous cohort of elite Polish half marathoners. The study group consisted of 180 elite half marathoners: 76 with time &lt; 100 minutes and 104 with time &gt; 100 minutes. DNA of the subjects was extracted from buccal cells donated by the runners and genotyping was carried out using an allelic discrimination assay with a C1000 Touch Thermal Cycler (Bio-Rad, Germany) instrument with TaqMan (R) probes (NOS3, UCP2, and AMPD1) and a T100 (TM) Thermal Cycler (Bio-Rad, Germany) instrument (ACE and BDKRB2). We found that the UCP2 Ala55Val polymorphism was associated with running performance, with the subjects carrying the Val allele being overrepresented in the group of most successful runners (&lt; 100 min) compared to the &gt; 100 min group (84.2 vs. 55.8%; OR = 4.23, p &lt; 0.0001). Next, to assess the combined impact of 4 gene polymorphisms, all athletes were classified according to the number of &apos;endurance&apos; alleles (ACE I, NOS3 Glu, BDKRB2 -9, UCP2 Val) they possessed. The proportion of subjects with a high (4-7) number of &apos;endurance&apos; alleles was greater in the better half marathoners group compared with the &gt; 100 min group (73.7 vs. 51.9%; OR = 2.6, p = 0.0034). These data suggest that the likelihood of becoming an elite half marathoner partly depends on the carriage of a high number of endurance-related alleles.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30306 - Sport and fitness sciences

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Human Kinetics

ISSN

1640-5544

e-ISSN

—

Svazek periodika

64

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

12

Strana od-do

87-98

Kód UT WoS článku

000447662500009

EID výsledku v databázi Scopus

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