Three weeks of intermittent hypoxic training affect antioxidant enzyme activity and increases lipid peroxidation in cyclists

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11510%2F19%3A10398294" target="_blank" >RIV/00216208:11510/19:10398294 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Sh0kneKIt5" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Sh0kneKIt5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00706-019-02451-1" target="_blank" >10.1007/s00706-019-02451-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Three weeks of intermittent hypoxic training affect antioxidant enzyme activity and increases lipid peroxidation in cyclists

Popis výsledku v původním jazyce

The aim of the present study was to evaluate the influence of intermittent hypoxic training (IHT) on antioxidant status in elite cyclists. Fifteen male, elite cyclists were randomly divided into the IHT group (IHT-G) and a normoxia control group (CG). The subjects in IHT-G exercised under normobaric hypoxia environment (O-2 = 15.2%) at intensity of 95% of the lactate threshold (LT) for 3 weeks, whereas the CG exercised under normoxia with intensity of 100% LT. The following variables were measured: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), reduced glutathione (GSH), uric acid (UA), total antioxidant status (TAS), malondialdehyde (MDA), and creatine kinase (CK). All variables were evaluated at baseline and post-exercise, both at rest and following the progressive exercise test (PT). After 3 weeks of training, significant intragroup differences occurred in MDA, GSH, and TAS values, and in GPX and CK activity. There were also significant changes in IHT-G before the experiment and after the PT in SOD, GPX, and CK activity, and in levels of TAS and MDA. After the 3 weeks of training, and following the PT, there were significant differences in SOD, CAT, GPX, and CK activity as well as in levels of UA and MDA. In the CG, before and after the intervention, and the PT, SOD, CAT, and CK activity as well as UA, TAS, and MDA concentrations were significantly different from resting condition. IHT significantly affects SOD, CAT, and MDA in competitive cyclists. We observed lower antioxidant enzyme activity and higher MDA concentration in the IHT-G compared to the CG. This confirms that exercise under hypoxia generates higher oxidative stress than the same training loads performed under normoxia conditions. [GRAPHICS] .

Název v anglickém jazyce

Three weeks of intermittent hypoxic training affect antioxidant enzyme activity and increases lipid peroxidation in cyclists

Popis výsledku anglicky

The aim of the present study was to evaluate the influence of intermittent hypoxic training (IHT) on antioxidant status in elite cyclists. Fifteen male, elite cyclists were randomly divided into the IHT group (IHT-G) and a normoxia control group (CG). The subjects in IHT-G exercised under normobaric hypoxia environment (O-2 = 15.2%) at intensity of 95% of the lactate threshold (LT) for 3 weeks, whereas the CG exercised under normoxia with intensity of 100% LT. The following variables were measured: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), reduced glutathione (GSH), uric acid (UA), total antioxidant status (TAS), malondialdehyde (MDA), and creatine kinase (CK). All variables were evaluated at baseline and post-exercise, both at rest and following the progressive exercise test (PT). After 3 weeks of training, significant intragroup differences occurred in MDA, GSH, and TAS values, and in GPX and CK activity. There were also significant changes in IHT-G before the experiment and after the PT in SOD, GPX, and CK activity, and in levels of TAS and MDA. After the 3 weeks of training, and following the PT, there were significant differences in SOD, CAT, GPX, and CK activity as well as in levels of UA and MDA. In the CG, before and after the intervention, and the PT, SOD, CAT, and CK activity as well as UA, TAS, and MDA concentrations were significantly different from resting condition. IHT significantly affects SOD, CAT, and MDA in competitive cyclists. We observed lower antioxidant enzyme activity and higher MDA concentration in the IHT-G compared to the CG. This confirms that exercise under hypoxia generates higher oxidative stress than the same training loads performed under normoxia conditions. [GRAPHICS] .

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30306 - Sport and fitness sciences

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Monatshefte für Chemie - Chemical Monthly

ISSN

0026-9247

e-ISSN

—

Svazek periodika

150

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

8

Strana od-do

1703-1710

Kód UT WoS článku

000482907600021

EID výsledku v databázi Scopus

2-s2.0-85070199030