Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11510%2F20%3A10400598" target="_blank" >RIV/00216208:11510/20:10400598 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=oU3gI7ixlS" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=oU3gI7ixlS</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.comppsych.2019.152143" target="_blank" >10.1016/j.comppsych.2019.152143</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort

Popis výsledku v původním jazyce

Background: Meta-analyses confirm increased circulating C-reactive protein (CRP) levels in depression.Longitudinal studies have linked one-off measurements of CRP at baseline with increased risk of devel-oping depressive symptoms subsequently at follow-up, but studies with repeat CRP measures from thesame individuals are scarce.Methods: We have examined whether longitudinal patterns of inflammation, based on three CRP measure-ments from childhood to early-adulthood, are associated with the risk of depression in early-adulthoodin the Avon Longitudinal Study of Parents and Children, a prospective birth cohort.Results: Using Gaussian mixture modelling of available CRP data from age 9, 15 and 18 years, we identifiedfour population clusters/sub-groups reflecting different longitudinal patterns of CRP: persistently low(N = 463, 29.5%); persistently high (N = 371, 24%); decreasing (N = 360, 23%); increasing (N = 367, 23.5%).The increasing group showed a steep increase in CRP levels between adolescence and early-adulthood.Participants in this group had a higher risk of moderate/severe depression at age 18 years, compared withthose with persistently low CRP; adjusted odds ratio (OR) = 3.78 (95% Confidence Interval (CI), 1.46-9.81;p = 0.006). The odds of moderate/severe depression were also increased for the persistently high CRPgroup, but this was not statistically significant; OR = 2.54 (95% CI, 0.90-7.16).Limitations: Repeat CRP measures were available for a subset, who may not be representative of all cohortparticipants.Conclusions: The results suggest that an increasing pattern of inflammation from adolescence to early-adulthood is associated with risk of depression in early-adulthood.

Název v anglickém jazyce

Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort

Popis výsledku anglicky

Background: Meta-analyses confirm increased circulating C-reactive protein (CRP) levels in depression.Longitudinal studies have linked one-off measurements of CRP at baseline with increased risk of devel-oping depressive symptoms subsequently at follow-up, but studies with repeat CRP measures from thesame individuals are scarce.Methods: We have examined whether longitudinal patterns of inflammation, based on three CRP measure-ments from childhood to early-adulthood, are associated with the risk of depression in early-adulthoodin the Avon Longitudinal Study of Parents and Children, a prospective birth cohort.Results: Using Gaussian mixture modelling of available CRP data from age 9, 15 and 18 years, we identifiedfour population clusters/sub-groups reflecting different longitudinal patterns of CRP: persistently low(N = 463, 29.5%); persistently high (N = 371, 24%); decreasing (N = 360, 23%); increasing (N = 367, 23.5%).The increasing group showed a steep increase in CRP levels between adolescence and early-adulthood.Participants in this group had a higher risk of moderate/severe depression at age 18 years, compared withthose with persistently low CRP; adjusted odds ratio (OR) = 3.78 (95% Confidence Interval (CI), 1.46-9.81;p = 0.006). The odds of moderate/severe depression were also increased for the persistently high CRPgroup, but this was not statistically significant; OR = 2.54 (95% CI, 0.90-7.16).Limitations: Repeat CRP measures were available for a subset, who may not be representative of all cohortparticipants.Conclusions: The results suggest that an increasing pattern of inflammation from adolescence to early-adulthood is associated with risk of depression in early-adulthood.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30306 - Sport and fitness sciences

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Comprehensive Psychiatry

ISSN

0010-440X

e-ISSN

—

Svazek periodika

96

Číslo periodika v rámci svazku

neuvedeno

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

1-7

Kód UT WoS článku

000525757200006

EID výsledku v databázi Scopus

2-s2.0-85074455744