Evidence of hypothalamic-pituitary-adrenal and -gonadal dysfunction in cocaine-addicted men

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11510%2F24%3A10472270" target="_blank" >RIV/00216208:11510/24:10472270 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Qdd1ZMirV0" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Qdd1ZMirV0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.17863/CAM.104419" target="_blank" >10.17863/CAM.104419</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evidence of hypothalamic-pituitary-adrenal and -gonadal dysfunction in cocaine-addicted men

Popis výsledku v původním jazyce

Regular cocaine use has been associated with hormonal dysfunction including hypogonadism, which can lead to fatigue, reduced stamina, sexual dysfunction and impaired quality of life. However, cocaine&apos;s endocrine effects are largely under-reported in the scientific addiction literature and, in many cases, are not addressed within treatment services. The low profile of these adverse effects might be attributable to a lack of awareness and linkage with cocaine use, such that they are recognized only when an acute/emergency problem arises. Methods: We assessed endocrine diurnal function [adrenocorticotrophic hormone (ACTH), cortisol and testosterone in 26 healthy and 27 cocaine-dependent men and examined changes in hormone levels in response to a single 40 mg dose of the noradrenaline re-uptake inhibitor atomoxetine in a double-blind, placebo-controlled experimental medicine study. Results: When compared with healthy controls, diurnal and atomoxetine-induced changes in ACTH and cortisol showed greater variability in cocaine-dependent men. Interestingly, despite an exaggerated rise in ACTH following atomoxetine, an attenuated cortisol response was observed, and one third of cocaine-dependent men had subnormal testosterone levels. Conclusion: Our findings point to a potential disconnection between the pituitary and adrenal responses in cocaine-dependent men, a higher rate of hypogonadism, and a pressing need for more research into the endocrine effects of cocaine and their clinical implications.

Název v anglickém jazyce

Evidence of hypothalamic-pituitary-adrenal and -gonadal dysfunction in cocaine-addicted men

Popis výsledku anglicky

Regular cocaine use has been associated with hormonal dysfunction including hypogonadism, which can lead to fatigue, reduced stamina, sexual dysfunction and impaired quality of life. However, cocaine&apos;s endocrine effects are largely under-reported in the scientific addiction literature and, in many cases, are not addressed within treatment services. The low profile of these adverse effects might be attributable to a lack of awareness and linkage with cocaine use, such that they are recognized only when an acute/emergency problem arises. Methods: We assessed endocrine diurnal function [adrenocorticotrophic hormone (ACTH), cortisol and testosterone in 26 healthy and 27 cocaine-dependent men and examined changes in hormone levels in response to a single 40 mg dose of the noradrenaline re-uptake inhibitor atomoxetine in a double-blind, placebo-controlled experimental medicine study. Results: When compared with healthy controls, diurnal and atomoxetine-induced changes in ACTH and cortisol showed greater variability in cocaine-dependent men. Interestingly, despite an exaggerated rise in ACTH following atomoxetine, an attenuated cortisol response was observed, and one third of cocaine-dependent men had subnormal testosterone levels. Conclusion: Our findings point to a potential disconnection between the pituitary and adrenal responses in cocaine-dependent men, a higher rate of hypogonadism, and a pressing need for more research into the endocrine effects of cocaine and their clinical implications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30306 - Sport and fitness sciences

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Addiction Research

ISSN

1022-6877

e-ISSN

1421-9891

Svazek periodika

30

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

114-120

Kód UT WoS článku

001144195600001

EID výsledku v databázi Scopus

2-s2.0-85182890224