Effects of psychopharmacotherapy on phenotypic expression of cytochrome P450 2D6 in patients genotyped for CYP2D6 mutations

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F00%3A00002245" target="_blank" >RIV/00216224:14110/00:00002245 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Jazyk výsledku
angličtina
Název v původním jazyce
Effects of psychopharmacotherapy on phenotypic expression of cytochrome P450 2D6 in patients genotyped for CYP2D6 mutations
Popis výsledku v původním jazyce
Twenty psychiatric patients were investigated for their CYP2D6 genotype and phenotype. Eight patients were pretreated with CYP2D6 substrate drugs, another 12 were therapy free. Genotyping with PCR for mutations in exon 3, 4 and 5 of CYP2D6 gene detected65% of patients as heterozygously mutated in exon 4. The phenotyping test showed a significantly higher occurence of poor metabolizers in patients pretreated with CYP2D6 substrate drugs that within those without previous therapy.
Název v anglickém jazyce
Effects of psychopharmacotherapy on phenotypic expression of cytochrome P450 2D6 in patients genotyped for CYP2D6 mutations
Popis výsledku anglicky
Twenty psychiatric patients were investigated for their CYP2D6 genotype and phenotype. Eight patients were pretreated with CYP2D6 substrate drugs, another 12 were therapy free. Genotyping with PCR for mutations in exon 3, 4 and 5 of CYP2D6 gene detected65% of patients as heterozygously mutated in exon 4. The phenotyping test showed a significantly higher occurence of poor metabolizers in patients pretreated with CYP2D6 substrate drugs that within those without previous therapy.

Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Rok uplatnění
2000
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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