Immune response to the herpes simplex type 1 regulatory proteins ICP8 and VP16 in infected persons

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F00%3A00035789" target="_blank" >RIV/00216224:14110/00:00035789 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Immune response to the herpes simplex type 1 regulatory proteins ICP8 and VP16 in infected persons

Popis výsledku v původním jazyce

The specific immune responses directed against the viral single stranded (ss) DNA binding protein ICP8 and the transactivator of immediate early (IE) gene expression VP16 (alpha-trans inducing factor, Vmw65) in HSV type 1 seropositive humans were examined. The results described in this paper indicate that neither ICP8 nor VP16 were able to induce a recall response in lymphocytes of healthy HSV seropositive individuals without recurrent infection, although CD4+ T cells purified from these individuals responded to both viral proteins in vitro when monocyte derived dendritic cells were used as antigen presenting cells. A recall response, however, could be induced to both viral proteins in T cells of patients with recurrent HSV infections when blood monocytes were used. Moreover, ICP8- and VP16-specific antibodies could be detected in the serum of patients with recurrent HSV infections whereas, in contrast, these antibodies were virtually absent in healthy HSV seropositive individuals with

Název v anglickém jazyce

Immune response to the herpes simplex type 1 regulatory proteins ICP8 and VP16 in infected persons

Popis výsledku anglicky

The specific immune responses directed against the viral single stranded (ss) DNA binding protein ICP8 and the transactivator of immediate early (IE) gene expression VP16 (alpha-trans inducing factor, Vmw65) in HSV type 1 seropositive humans were examined. The results described in this paper indicate that neither ICP8 nor VP16 were able to induce a recall response in lymphocytes of healthy HSV seropositive individuals without recurrent infection, although CD4+ T cells purified from these individuals responded to both viral proteins in vitro when monocyte derived dendritic cells were used as antigen presenting cells. A recall response, however, could be induced to both viral proteins in T cells of patients with recurrent HSV infections when blood monocytes were used. Moreover, ICP8- and VP16-specific antibodies could be detected in the serum of patients with recurrent HSV infections whereas, in contrast, these antibodies were virtually absent in healthy HSV seropositive individuals with

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2000

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF MEDICAL VIROLOGY

ISSN

0146-6615

e-ISSN

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Svazek periodika

62

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

000088492800005

EID výsledku v databázi Scopus

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