Duration of NIDDM and the TNFb NcoI genotype as predictive factors in proliferative diabetic retinopathy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F01%3A00002752" target="_blank" >RIV/00216224:14110/01:00002752 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Duration of NIDDM and the TNFb NcoI genotype as predictive factors in proliferative diabetic retinopathy

Popis výsledku v původním jazyce

The object of the study was to investigate the share of polymorphisms I/D ACE, endothelin-1 4127G/A and TNFb NcoI in the susceptibility to proliferative diabetic retinopathy (PDR) in non-insulin dependent diabetes mellitus (NIDDM). Genotypes were detected by polymerase chain reactions and determined in a set of 246 Caucasian NIDDM subjects with defined PDR status. The relevance of genotypes and clinical characteristics to the PDR occurrence was tested using multiple linear regression models and discrimination analysis. The best predictive value for PDR was given by a combination of two parameters - NIDDM duration and the TNFb genotype (P<1*10-6 and P=1*10-2, respectively) with a correct retrograde prediction of 82.6%. A comparison of the TNFb NcoI allele frequencies revealed no difference between NIDDM and nondiabetic subjects (n=176), but a statistically significant difference was found between PDR and non-PDR NIDDM subjects (after a correction for the number of comparisons P=0.03); a

Název v anglickém jazyce

Duration of NIDDM and the TNFb NcoI genotype as predictive factors in proliferative diabetic retinopathy

Popis výsledku anglicky

The object of the study was to investigate the share of polymorphisms I/D ACE, endothelin-1 4127G/A and TNFb NcoI in the susceptibility to proliferative diabetic retinopathy (PDR) in non-insulin dependent diabetes mellitus (NIDDM). Genotypes were detected by polymerase chain reactions and determined in a set of 246 Caucasian NIDDM subjects with defined PDR status. The relevance of genotypes and clinical characteristics to the PDR occurrence was tested using multiple linear regression models and discrimination analysis. The best predictive value for PDR was given by a combination of two parameters - NIDDM duration and the TNFb genotype (P<1*10-6 and P=1*10-2, respectively) with a correct retrograde prediction of 82.6%. A comparison of the TNFb NcoI allele frequencies revealed no difference between NIDDM and nondiabetic subjects (n=176), but a statistically significant difference was found between PDR and non-PDR NIDDM subjects (after a correction for the number of comparisons P=0.03); a

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

—

Projekt

<a href="/cs/project/VS96097" target="_blank" >VS96097: Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Ophthalmologica

ISSN

0030-3755

e-ISSN

—

Svazek periodika

4

Číslo periodika v rámci svazku

215

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

5

Strana od-do

294

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—