Lack of association between atopic asthma and the tumor necrosis factor alpha -308 gene polymorphism in a Czech population

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00004573" target="_blank" >RIV/00216224:14110/02:00004573 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Lack of association between atopic asthma and the tumor necrosis factor alpha -308 gene polymorphism in a Czech population

Popis výsledku v původním jazyce

Susceptibility to the development of asthma and other atopic diseases is known to be associated with genetic components. Several investigators have linked the tumor necrosis factor (TNF) genes and nearby markers located on chromosome 6p to atopy and asthma. Recent study has demonstrated that the TNF-alpha*2 allele of a polymorphism in the TNF-alpha; gene promoter region (G-308 A) is associated with a higher risk for the development of atopy in Spanish patients. The objective of this study was to evaluate the possible role of two described bi-allelic polymorphisms in the TNF locus alpha;a G to A transition at position -308 in the promoter region of the TNF-alpha gene and an NcoI restriction fragment length polymorphism (RFLP) in the first intron (+252A/G) of the LT-alpha(TNF-beta) gene in atopic diseases in a Czech population. We investigated the distribution of these polymorphisms in a case-control study. The genotypes were determined in 151 patients with atopic asthma and 155 random-s

Název v anglickém jazyce

Lack of association between atopic asthma and the tumor necrosis factor alpha -308 gene polymorphism in a Czech population

Popis výsledku anglicky

Susceptibility to the development of asthma and other atopic diseases is known to be associated with genetic components. Several investigators have linked the tumor necrosis factor (TNF) genes and nearby markers located on chromosome 6p to atopy and asthma. Recent study has demonstrated that the TNF-alpha*2 allele of a polymorphism in the TNF-alpha; gene promoter region (G-308 A) is associated with a higher risk for the development of atopy in Spanish patients. The objective of this study was to evaluate the possible role of two described bi-allelic polymorphisms in the TNF locus alpha;a G to A transition at position -308 in the promoter region of the TNF-alpha gene and an NcoI restriction fragment length polymorphism (RFLP) in the first intron (+252A/G) of the LT-alpha(TNF-beta) gene in atopic diseases in a Czech population. We investigated the distribution of these polymorphisms in a case-control study. The genotypes were determined in 151 patients with atopic asthma and 155 random-s

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Investigational Allergology and Clinical Immunology

ISSN

1018-9068

e-ISSN

—

Svazek periodika

12

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

ES - Španělské království

Počet stran výsledku

6

Strana od-do

192

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—