Involvement of 5-HT1A and 5-HT1B Receptors in Modulation of Methamphetamine I.V. Self-Administration in Rats

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Involvement of 5-HT1A and 5-HT1B Receptors in Modulation of Methamphetamine I.V. Self-Administration in Rats

Popis výsledku v původním jazyce

Methamphetamine acts neurotoxically in the brain, also on the serotonergic system, what is believed to endorse its behavioral effects and abuse. Thus, the present study ascertained the effects of 5-HT1A and 5-HT1B receptor ligands on intake of methamphetamine in rats with dependence raised in i. v. self-administration procedure (a fixed-ratio schedule: FR). Rats with stable methamphetamine intake on FR3 were acutely pretreated with serotonergics 15 minutes prior to self-administration session. The intraperitoneal pretreatment used: a) saline solution as a control (2.0 ml/kg, n=6), b) 5-HT1A/B agonist RU24969 (0.5; 1.5 and 4.5 mg/kg, n=13), c) 5-HT1A agonist 8-OH-DPAT (0.3; 1.0 and 3.0 mg/kg, n=6, d) 5-HT1B agonist CGS 12066B (1.0; 5.0 and 15.0 mg/kg, n=10). Statistical analysis was performed by the Wilcoxon matched-pairs signed-ranks test, two-tailed. Agonist of 5-HT1A receptor subtype had no significant influence on methamphetamine intake. The drug intake was partially suppressed by m

Název v anglickém jazyce

Involvement of 5-HT1A and 5-HT1B Receptors in Modulation of Methamphetamine I.V. Self-Administration in Rats

Popis výsledku anglicky

Methamphetamine acts neurotoxically in the brain, also on the serotonergic system, what is believed to endorse its behavioral effects and abuse. Thus, the present study ascertained the effects of 5-HT1A and 5-HT1B receptor ligands on intake of methamphetamine in rats with dependence raised in i. v. self-administration procedure (a fixed-ratio schedule: FR). Rats with stable methamphetamine intake on FR3 were acutely pretreated with serotonergics 15 minutes prior to self-administration session. The intraperitoneal pretreatment used: a) saline solution as a control (2.0 ml/kg, n=6), b) 5-HT1A/B agonist RU24969 (0.5; 1.5 and 4.5 mg/kg, n=13), c) 5-HT1A agonist 8-OH-DPAT (0.3; 1.0 and 3.0 mg/kg, n=6, d) 5-HT1B agonist CGS 12066B (1.0; 5.0 and 15.0 mg/kg, n=10). Statistical analysis was performed by the Wilcoxon matched-pairs signed-ranks test, two-tailed. Agonist of 5-HT1A receptor subtype had no significant influence on methamphetamine intake. The drug intake was partially suppressed by m

Druh

D - Stať ve sborníku

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

The 7th NIDA International Forum

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

43

Název nakladatele

US National Institute on Drug Addiction (NIDA)

Místo vydání

Quebec, Canada

Místo konání akce

13. - 15. 6, 2002, Quebec, Canada

Datum konání akce

1. 1. 2002

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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