Office blood pressure, heart rate and interleukin-6 gene polymorphism in apparently healthy Czech middle-aged population

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00006403" target="_blank" >RIV/00216224:14110/02:00006403 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Office blood pressure, heart rate and interleukin-6 gene polymorphism in apparently healthy Czech middle-aged population

Popis výsledku v původním jazyce

The aim of the study was to assess the existence of association of promoter polymorphism [A (-597)G] in interleukin-6 gene with office systolic and diastolic blood pressures as well as with heart rate in apparently healthy Czech subjects. Another task was to evaluate possible influence of gender, BMI and smoking on these supposed associations. An age- (40-50 years) and sex-matched (F/M=81/89) sample of healthy Czech subjects (n=170,F/M=81/89) without previous personal history of hypertension, other cardiovascular diseases and/ or diabetes was formed. The A (-597) G IL-6 polymorphism was detected by PCR No differences in genotype distribution and/or allelic frequency was found between groups with "low" systolic blood pressure (below 122mm Hg) and "highsystolic blood pressure (above 122 mm Hg). Similarly, no differences in the IL-6 polymorphism were found between"low" (below 88 mm Hg) and "high" (above 88 mm Hg) diastolic blood pressure groups. But, significant differences were observed

Název v anglickém jazyce

Office blood pressure, heart rate and interleukin-6 gene polymorphism in apparently healthy Czech middle-aged population

Popis výsledku anglicky

The aim of the study was to assess the existence of association of promoter polymorphism [A (-597)G] in interleukin-6 gene with office systolic and diastolic blood pressures as well as with heart rate in apparently healthy Czech subjects. Another task was to evaluate possible influence of gender, BMI and smoking on these supposed associations. An age- (40-50 years) and sex-matched (F/M=81/89) sample of healthy Czech subjects (n=170,F/M=81/89) without previous personal history of hypertension, other cardiovascular diseases and/ or diabetes was formed. The A (-597) G IL-6 polymorphism was detected by PCR No differences in genotype distribution and/or allelic frequency was found between groups with "low" systolic blood pressure (below 122mm Hg) and "highsystolic blood pressure (above 122 mm Hg). Similarly, no differences in the IL-6 polymorphism were found between"low" (below 88 mm Hg) and "high" (above 88 mm Hg) diastolic blood pressure groups. But, significant differences were observed

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2002

Kód důvěrnosti údajů

C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

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Svazek periodika

2002

Číslo periodika v rámci svazku

in print

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

1

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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