Antidepressant-like effects of amisulpride in bubectomized male rats

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Antidepressant-like effects of amisulpride in bubectomized male rats

Popis výsledku v původním jazyce

Amisulpride is a benzamide derivative with unique neurochemical and psychopharmacological profiles, characterized by a preferential blockade of dopamine D2/D3 presynaptic autoreceptors in the limbic structures (Schoemaker et al., 1997) after low dosing and antagonism at postsynaptic D receptors after high doses (Coukell et al., 1996). There are clinical reports available about both antidepressant (in low dopaminergic doses) and antipsychotic (in high antidopaminergic doses) effects of amisulpride. Ratswith bilateral lesion of the olfactory bulb (OB rats) which are used as an animal model resembling behavioural and endocrine changes found in human depression were used in the present study to examine potential antidepressant effects of amisulpride. OB rats show significant increase in ambulation and rearing scores in "open-field" tests (Leonard, 1983) which is suppressed by clinically used antidepressants. Thus, both acute and repeated amisulpride treatment on locomotor behaviour (ambul

Název v anglickém jazyce

Antidepressant-like effects of amisulpride in bubectomized male rats

Popis výsledku anglicky

Amisulpride is a benzamide derivative with unique neurochemical and psychopharmacological profiles, characterized by a preferential blockade of dopamine D2/D3 presynaptic autoreceptors in the limbic structures (Schoemaker et al., 1997) after low dosing and antagonism at postsynaptic D receptors after high doses (Coukell et al., 1996). There are clinical reports available about both antidepressant (in low dopaminergic doses) and antipsychotic (in high antidopaminergic doses) effects of amisulpride. Ratswith bilateral lesion of the olfactory bulb (OB rats) which are used as an animal model resembling behavioural and endocrine changes found in human depression were used in the present study to examine potential antidepressant effects of amisulpride. OB rats show significant increase in ambulation and rearing scores in "open-field" tests (Leonard, 1983) which is suppressed by clinically used antidepressants. Thus, both acute and repeated amisulpride treatment on locomotor behaviour (ambul

Druh

D - Stať ve sborníku

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Neuroscience in the Third Millennium, X. International Congress of the Czech and Slovak Neurochemical Society

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

66

Název nakladatele

Czech and Slovak Neurochemical Society

Místo vydání

Častá, Slovakia

Místo konání akce

June 1-5, 2002 Častá, Slovakia

Datum konání akce

1. 1. 2002

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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