Relationship between genetic polymorphism of antioxidant enzymes and diabetic complications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F03%3A00008083" target="_blank" >RIV/00216224:14110/03:00008083 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Relationship between genetic polymorphism of antioxidant enzymes and diabetic complications

Popis výsledku v původním jazyce

Background and Aims: Association of genetic polymorphisms in glyoxalase I (A111E GLYI), paraoxonase (-107C/T, M55L and R192Q PON) and NAD(P)H: quinone oxidoreductase genes (P187S NQO1) with diabetes-associated microvascular dermatoses (DAMD) in patientswith type 2 diabetes mellitus and analogical microvascular dermatoses (MD) in non-diabetics was studied. Materials and Methods: A total of 456 subjects was enrolled in the association study comprising four groups of subjects: diabetics with and without DAMD and non-diabetics with and without MD. Results: Significant difference in genotype frequencies of the A111E GLYI between DAMD and non-DAMD group was found; frequency of the E allele was higher in DAMD group (58.8% vs. 55.6%). Moreover, marginally significant association of allele M with DAMD was detected for the M55L PON polymorphism (P=0.062); 67.3% in DAMD vs. 59.6% in non-DAMD group. When both DAMD/MD group pooled together, association of GLYI 111E and PON 55M with cutaneous manif

Název v anglickém jazyce

Relationship between genetic polymorphism of antioxidant enzymes and diabetic complications

Popis výsledku anglicky

Background and Aims: Association of genetic polymorphisms in glyoxalase I (A111E GLYI), paraoxonase (-107C/T, M55L and R192Q PON) and NAD(P)H: quinone oxidoreductase genes (P187S NQO1) with diabetes-associated microvascular dermatoses (DAMD) in patientswith type 2 diabetes mellitus and analogical microvascular dermatoses (MD) in non-diabetics was studied. Materials and Methods: A total of 456 subjects was enrolled in the association study comprising four groups of subjects: diabetics with and without DAMD and non-diabetics with and without MD. Results: Significant difference in genotype frequencies of the A111E GLYI between DAMD and non-DAMD group was found; frequency of the E allele was higher in DAMD group (58.8% vs. 55.6%). Moreover, marginally significant association of allele M with DAMD was detected for the M55L PON polymorphism (P=0.062); 67.3% in DAMD vs. 59.6% in non-DAMD group. When both DAMD/MD group pooled together, association of GLYI 111E and PON 55M with cutaneous manif

Druh

D - Stať ve sborníku

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/GP303%2F02%2FD127" target="_blank" >GP303/02/D127: Vztah genetické variability antioxidačního systému k pozdním komplikacím diabetu mellitu</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Stress, Signalling and Control

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

59

Název nakladatele

Biochemical Society

Místo vydání

London, Great Britain

Místo konání akce

University of Essex, UK

Datum konání akce

1. 1. 2003

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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