Antidepressant-like effects of felbamate on locomotor behaviour and leukocyte phagocytosis in rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F03%3A00009203" target="_blank" >RIV/00216224:14110/03:00009203 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Antidepressant-like effects of felbamate on locomotor behaviour and leukocyte phagocytosis in rats

Popis výsledku v původním jazyce

To examine potential antidepressant effects of felbamate rats with bilateral lesion of the olfactory bulb (OB rats) were used in the present study. This animal model resembles behavioural, endocrine and immune changes found in human depression. Repeatedfelbamate treatment (240 mg/kg, orally, for 10 days) effects on locomotor behaviour (ambulation) in an open field test, and on leukocyte phagocytosis were studied in both sham-operated and bulbectomized rats. Felbamate elicited a significant decrease ofthe previously hyperactive ambulation of the OB rats after 10 days of medication (240 mg/kg/day, orally), while no marked changes were observed in sham-operated animals. On the day 10 of the felbamate treatment, there was no significant difference in locomotor activity of the OB and the sham-operated rats. Significantly suppressed leukocyte phagocytic activity recorded in OB rats was disinhibited in those treated repeatedly with felbamate while the drug did not alter phagocytosis of leuk

Název v anglickém jazyce

Antidepressant-like effects of felbamate on locomotor behaviour and leukocyte phagocytosis in rats

Popis výsledku anglicky

To examine potential antidepressant effects of felbamate rats with bilateral lesion of the olfactory bulb (OB rats) were used in the present study. This animal model resembles behavioural, endocrine and immune changes found in human depression. Repeatedfelbamate treatment (240 mg/kg, orally, for 10 days) effects on locomotor behaviour (ambulation) in an open field test, and on leukocyte phagocytosis were studied in both sham-operated and bulbectomized rats. Felbamate elicited a significant decrease ofthe previously hyperactive ambulation of the OB rats after 10 days of medication (240 mg/kg/day, orally), while no marked changes were observed in sham-operated animals. On the day 10 of the felbamate treatment, there was no significant difference in locomotor activity of the OB and the sham-operated rats. Significantly suppressed leukocyte phagocytic activity recorded in OB rats was disinhibited in those treated repeatedly with felbamate while the drug did not alter phagocytosis of leuk

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Neuropsychopharmacology

ISSN

0924-977X

e-ISSN

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Svazek periodika

13

Číslo periodika v rámci svazku

Suppl.4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

1

Strana od-do

216

Kód UT WoS článku

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EID výsledku v databázi Scopus

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