Vliv agonisty kanabinoidního receptoru CB2 JWH015 na rozvoj sensitizace v modelu agonistického chování myší

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00010239" target="_blank" >RIV/00216224:14110/04:00010239 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour

Popis výsledku v původním jazyce

The aim of the present study was to investigate whether the CB2 receptor activity might also be involved in regulation of mouse agonistic behaviour, and in development of sensitivity to methamphetamine.The CB2 agonist JWH-015 given alone to aggressive singly-housed mice at the doses of 0.1, 1.0 and 10.0 mg/kg intraperitoneally 15 min prior to testing inhibited the occurrence of aggressive activities, significantly of tail rattling and threat after the highest dose. The expression of significant sensitization to MET antiaggressive effects was clear after the pre-treatment with 5 MET doses of 1 mg/kg/day and administration of the "challenge dose" of 1 mg/kg after 5 days of withdrawal. However, the pretreatment with JWH (5 daily doses of 1.0 mg/kg) the cross-sensitization to MET "challenge dose" did not produce in the present study.

Název v anglickém jazyce

The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour

Popis výsledku anglicky

The aim of the present study was to investigate whether the CB2 receptor activity might also be involved in regulation of mouse agonistic behaviour, and in development of sensitivity to methamphetamine.The CB2 agonist JWH-015 given alone to aggressive singly-housed mice at the doses of 0.1, 1.0 and 10.0 mg/kg intraperitoneally 15 min prior to testing inhibited the occurrence of aggressive activities, significantly of tail rattling and threat after the highest dose. The expression of significant sensitization to MET antiaggressive effects was clear after the pre-treatment with 5 MET doses of 1 mg/kg/day and administration of the "challenge dose" of 1 mg/kg after 5 days of withdrawal. However, the pretreatment with JWH (5 daily doses of 1.0 mg/kg) the cross-sensitization to MET "challenge dose" did not produce in the present study.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Homeostasis in Health and Diseases

ISSN

0960-7560

e-ISSN

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Svazek periodika

43

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

2

Strana od-do

41-42

Kód UT WoS článku

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EID výsledku v databázi Scopus

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