SEnsitizace a krossensitizace kanabinoidem k inhibičnímu účinku metamfetaminu na agresivitu myší se nevzniká v řpípadě aplikace morfinu

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00010246" target="_blank" >RIV/00216224:14110/04:00010246 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Sensitization and cannabinoid cross-sensitization to methamphetamine antiaggressive effects is not developed in morphine treatment design in mice

Popis výsledku v původním jazyce

Repeated drug administration leading to a progressively enhanced response, a phenomenon termed sensitization, may be involved in the development and maintenance of drug addiction and also relapse to drug-taking behaviour in weaned addicts. There also isdata available showing a cross-sensitization between different types of drugs of abuse. The present study observed behavioural sensitization to the psychostimulant methamphetamine (MET), the opioid morphine (MO) and cross-sensitization with cannabinoid methanandamide (CA) to both of them in mice. The model of agonistic behaviour in singly-housed male mice on paired interactions with non-aggressive group-housed partners was used to analyze behavioural changes in 15 acts of 4 categories: sociable, timid,aggressive and locomotor. Both MET and MO produce dose-dependent antiaggressive effects in singly-housed mice; MET increased while MO decreased locomotor activities. The sensitization to these effects of MET was clearly demonstrated when

Název v anglickém jazyce

Sensitization and cannabinoid cross-sensitization to methamphetamine antiaggressive effects is not developed in morphine treatment design in mice

Popis výsledku anglicky

Repeated drug administration leading to a progressively enhanced response, a phenomenon termed sensitization, may be involved in the development and maintenance of drug addiction and also relapse to drug-taking behaviour in weaned addicts. There also isdata available showing a cross-sensitization between different types of drugs of abuse. The present study observed behavioural sensitization to the psychostimulant methamphetamine (MET), the opioid morphine (MO) and cross-sensitization with cannabinoid methanandamide (CA) to both of them in mice. The model of agonistic behaviour in singly-housed male mice on paired interactions with non-aggressive group-housed partners was used to analyze behavioural changes in 15 acts of 4 categories: sociable, timid,aggressive and locomotor. Both MET and MO produce dose-dependent antiaggressive effects in singly-housed mice; MET increased while MO decreased locomotor activities. The sensitization to these effects of MET was clearly demonstrated when

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Fundamental & Clinical Pharmacology

ISSN

1744-3377

e-ISSN

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Svazek periodika

18

Číslo periodika v rámci svazku

Suppl.1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

1

Strana od-do

58

Kód UT WoS článku

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EID výsledku v databázi Scopus

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