Vliv aktivity kanabinoidních receptorů CB2 na agresivitu u myší a sensitizacei k antiagresivnímu účinku metamfetaminu

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00010247" target="_blank" >RIV/00216224:14110/04:00010247 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Impact of cannabinoid CB2 receptor activity on aggressive behaviour in mice and senistization to methamphetamine antiaggressive effects.

Popis výsledku v původním jazyce

Impact of cannabinoid CB2 receptor activity on aggressive behavior in mice and sensitization to methamphetamine antiaggresive effects. Cannabinoid receptor CB2 is localized mainly outside of the CNS. Thus a poor impact of its activity on behavior can beexpected. Previously we found development of both sensitization to methamphetamine (MET) antiaggressive effects by pre-treatment with repeated MET doses and a cross-sensitization to this MET effect with cannabinoid CB1 receptor agonist methanandamide inthe model of agonistic behaviour in singly-housed male mice on paired interactions with non-aggressive group-housed partners. This supported the evidence of interaction between the endocannabinoid system and MET brain mechanism. The aim of the present study was to investigate whether the CB2 receptor activity might also be involved in regulation of mouse agonistic behaviour, and in development of sensitivity to methamphetamine. Therefore the CB2 receptor agonist JWH 015 (JWH) has been te

Název v anglickém jazyce

Impact of cannabinoid CB2 receptor activity on aggressive behaviour in mice and senistization to methamphetamine antiaggressive effects.

Popis výsledku anglicky

Impact of cannabinoid CB2 receptor activity on aggressive behavior in mice and sensitization to methamphetamine antiaggresive effects. Cannabinoid receptor CB2 is localized mainly outside of the CNS. Thus a poor impact of its activity on behavior can beexpected. Previously we found development of both sensitization to methamphetamine (MET) antiaggressive effects by pre-treatment with repeated MET doses and a cross-sensitization to this MET effect with cannabinoid CB1 receptor agonist methanandamide inthe model of agonistic behaviour in singly-housed male mice on paired interactions with non-aggressive group-housed partners. This supported the evidence of interaction between the endocannabinoid system and MET brain mechanism. The aim of the present study was to investigate whether the CB2 receptor activity might also be involved in regulation of mouse agonistic behaviour, and in development of sensitivity to methamphetamine. Therefore the CB2 receptor agonist JWH 015 (JWH) has been te

Druh

A - Audiovizuální tvorba

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

ISBN

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Místo vydání

Portugalsko

Název nakladatele resp. objednatele

FENS

Verze

CD - FENS Forum 2004

Identifikační číslo nosiče

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