Porovnání úlohy receptorů 5-HT1 a 5-HT2 v regulaci lokomočně-pátracího chování potaknů

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00010698" target="_blank" >RIV/00216224:14110/04:00010698 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Comparison of the role of 5-HT1 and 5-HT2 receptors in the regulation of locomotor/exploratory behaviour in rats

Popis výsledku v původním jazyce

The aim of the present study was to ascertain the role of serotonin (5-HT) on locomotor/exploratory behaviour in laboratory rats. In the experiments, activity of selected 5-HT receptor subtypes was manipulated by exogenous administration of their ligands. We focused on the evaluation of influence of 5-HT1A and 5-HT1B selective receptor ligands, and furthermore non-selective 5-HT2 receptor agents. We used two behavioural tests: "staircase test" (climbing the stairs and rearing are recorded) and "open field" test performed by Actitrack apparatus (Panlab, S.L., Spain) that enables recording of wide range of behavioural parameters. In comparison of the influences of all 5-HT1A, 5-HT1B and 5-HT2 ligands tested on spontaneous locomotor/exploratory activitiesof animals there has been shown that the selective 5-HT1A mimetic agent 8-OH-DPAT possesses the most significant inhibitory efficacy.Present results underline the role of 5-HT1A receptor subtype in the mediation of locomotor/exploratory

Název v anglickém jazyce

Comparison of the role of 5-HT1 and 5-HT2 receptors in the regulation of locomotor/exploratory behaviour in rats

Popis výsledku anglicky

The aim of the present study was to ascertain the role of serotonin (5-HT) on locomotor/exploratory behaviour in laboratory rats. In the experiments, activity of selected 5-HT receptor subtypes was manipulated by exogenous administration of their ligands. We focused on the evaluation of influence of 5-HT1A and 5-HT1B selective receptor ligands, and furthermore non-selective 5-HT2 receptor agents. We used two behavioural tests: "staircase test" (climbing the stairs and rearing are recorded) and "open field" test performed by Actitrack apparatus (Panlab, S.L., Spain) that enables recording of wide range of behavioural parameters. In comparison of the influences of all 5-HT1A, 5-HT1B and 5-HT2 ligands tested on spontaneous locomotor/exploratory activitiesof animals there has been shown that the selective 5-HT1A mimetic agent 8-OH-DPAT possesses the most significant inhibitory efficacy.Present results underline the role of 5-HT1A receptor subtype in the mediation of locomotor/exploratory

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GP305%2F02%2FD130" target="_blank" >GP305/02/D130: Funkční úloha serotoninového 5-HT2 receptorového podtypu při rozvoji závislosti na metamfetamin</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Homeostasis

ISSN

0960-7560

e-ISSN

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Svazek periodika

43

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

3

Strana od-do

46-48

Kód UT WoS článku

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EID výsledku v databázi Scopus

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