Vliv metamfetaminu na farmakokinetiku dextrometorfanu a midazolamu.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00014064" target="_blank" >RIV/00216224:14110/05:00014064 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effect of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats.

Popis výsledku v původním jazyce

Methamphetamine is the fourth most frequently cited drug of abuse on treatment centre admission records behind cocaine, heroin and marijuana. We investigated the effect of methamphetamine (10 mg/kg, i.p., once daily for six days) on the pharmacokineticsof midazolam a substrate for rat cytochrome P-450 3A. Animals received a single injection of midazolam (5 mg/kg) in tail vein 24 h after the last dose of methamphetamine and placebo. Validated HPLC method was used to quantify all compounds of interest. The elimination half-life (t1/2) and the area under the concentration-time curve of midazolam were significantly reduced by pretreatment with methamphetamine to 63.8 % and 66.3 of control value, respectively and the clearance of midazolam was significantly increased by methamphetamine pretreatment. The results showed that administration of methamphetamine significantly stimulated metabolic activity of CYP3A1/2. With regard to a high level of homology between human and rat CYP isoforms stu

Název v anglickém jazyce

Effect of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats.

Popis výsledku anglicky

Methamphetamine is the fourth most frequently cited drug of abuse on treatment centre admission records behind cocaine, heroin and marijuana. We investigated the effect of methamphetamine (10 mg/kg, i.p., once daily for six days) on the pharmacokineticsof midazolam a substrate for rat cytochrome P-450 3A. Animals received a single injection of midazolam (5 mg/kg) in tail vein 24 h after the last dose of methamphetamine and placebo. Validated HPLC method was used to quantify all compounds of interest. The elimination half-life (t1/2) and the area under the concentration-time curve of midazolam were significantly reduced by pretreatment with methamphetamine to 63.8 % and 66.3 of control value, respectively and the clearance of midazolam was significantly increased by methamphetamine pretreatment. The results showed that administration of methamphetamine significantly stimulated metabolic activity of CYP3A1/2. With regard to a high level of homology between human and rat CYP isoforms stu

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Eur J Drug Metab Pharmacokinet

ISSN

0378-7966

e-ISSN

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Svazek periodika

30

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

000232621200008

EID výsledku v databázi Scopus

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