Physiological role of transverse-axial tubular system in cardiac ventricular myocytes: a simulation study

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00014795" target="_blank" >RIV/00216224:14110/05:00014795 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Jazyk výsledku
angličtina
Název v původním jazyce
Physiological role of transverse-axial tubular system in cardiac ventricular myocytes: a simulation study
Popis výsledku v původním jazyce
Experimental data related to the transverse - axial tubular system of guinea pig and rat ventricular myocytes were incorporated into quantitative models of their electrical activity. The results of simulations suggest that activity-dependent depletion ofCa within the tubular lumen decreases the intracellular Ca-load and intracellular Ca-transients in both species. However, considerable species differences in the magnitude of the depletion, its frequency dependence and the resulting effect on cellular activity were observed.
Název v anglickém jazyce
Physiological role of transverse-axial tubular system in cardiac ventricular myocytes: a simulation study
Popis výsledku anglicky
Experimental data related to the transverse - axial tubular system of guinea pig and rat ventricular myocytes were incorporated into quantitative models of their electrical activity. The results of simulations suggest that activity-dependent depletion ofCa within the tubular lumen decreases the intracellular Ca-load and intracellular Ca-transients in both species. However, considerable species differences in the magnitude of the depletion, its frequency dependence and the resulting effect on cellular activity were observed.

Rok uplatnění
2005
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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