Matrixmetaloproteinázy v imunopatogenezi roztroušené sklerózy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00014830" target="_blank" >RIV/00216224:14110/05:00014830 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Matrixmetalloproteinases in the immunopathogenesis of multiple sclerosis

Popis výsledku v původním jazyce

Multiple sclerosis (MS) is a chronic autoimmune disorder of the CNS. Matrixmetalloproteinases (MMPs) play a key role in the immunopathogenesis of MS and are significant contributors to the progression of the inflammatory process. There are 23 MMPs knownto play a role in the MS disease process. The aim of this study was to analyse the activity of MMP-2 and TIMP-2 in multiple sclerosis and to assess their relationship to the form of the disease. There were 50 patients with definite multiple sclerosis (mean age: 36+/-8 years, mean EDSS score 3.8+/-1.8) studied. Serum levels of MMP-2 and TIMP-2 were quantified by ELISA method in 30 patients with relapsing-remitting form, 10 with definite secondary progressive and 10 with primary progressive form of the disease and compared with those of 50 healthy controls (mean age 36+/-9 years). Mean protein serum levels in control group were: TIMP-2: 47.9 ng/ml, MMP-2: 1887.6 ng/ml. In MS group serum levels were: TIMP-2 46.1 ng/ml, MMP-2 1967.7 ng/ml,

Název v anglickém jazyce

Matrixmetalloproteinases in the immunopathogenesis of multiple sclerosis

Popis výsledku anglicky

Multiple sclerosis (MS) is a chronic autoimmune disorder of the CNS. Matrixmetalloproteinases (MMPs) play a key role in the immunopathogenesis of MS and are significant contributors to the progression of the inflammatory process. There are 23 MMPs knownto play a role in the MS disease process. The aim of this study was to analyse the activity of MMP-2 and TIMP-2 in multiple sclerosis and to assess their relationship to the form of the disease. There were 50 patients with definite multiple sclerosis (mean age: 36+/-8 years, mean EDSS score 3.8+/-1.8) studied. Serum levels of MMP-2 and TIMP-2 were quantified by ELISA method in 30 patients with relapsing-remitting form, 10 with definite secondary progressive and 10 with primary progressive form of the disease and compared with those of 50 healthy controls (mean age 36+/-9 years). Mean protein serum levels in control group were: TIMP-2: 47.9 ng/ml, MMP-2: 1887.6 ng/ml. In MS group serum levels were: TIMP-2 46.1 ng/ml, MMP-2 1967.7 ng/ml,

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Multiple sclerosis

ISSN

1352-4585

e-ISSN

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Svazek periodika

11

Číslo periodika v rámci svazku

Suppl. 1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

1

Strana od-do

120

Kód UT WoS článku

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EID výsledku v databázi Scopus

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