A keratinocyte-produced inhibitor is differentially active against two isoforms of MSF

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00016675" target="_blank" >RIV/00216224:14110/06:00016675 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A keratinocyte-produced inhibitor is differentially active against two isoforms of MSF

Popis výsledku v původním jazyce

MSF is a truncated (70kDa) isoform of fibronecting displaying number of potent biactivities mediated by IGD-amino acid motif. Two MSF isoforms, differing in terms of 15 amino acid deletion in a module II-1, have been identified. While IGD-mediated bioactivities od both isoforms are identical, deleted isoform (MSF-aa) is not inhibited by recently characterised inhibitor produced by normal keratinocytes. Furthermore, various cancer cell lines produce MSF activity which is not inhibited or partly inhibitedby MSF inhibitor.

Název v anglickém jazyce

A keratinocyte-produced inhibitor is differentially active against two isoforms of MSF

Popis výsledku anglicky

MSF is a truncated (70kDa) isoform of fibronecting displaying number of potent biactivities mediated by IGD-amino acid motif. Two MSF isoforms, differing in terms of 15 amino acid deletion in a module II-1, have been identified. While IGD-mediated bioactivities od both isoforms are identical, deleted isoform (MSF-aa) is not inhibited by recently characterised inhibitor produced by normal keratinocytes. Furthermore, various cancer cell lines produce MSF activity which is not inhibited or partly inhibitedby MSF inhibitor.

Druh

O - Ostatní výsledky

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/LZ1K03019" target="_blank" >LZ1K03019: Zlepšení hojení ran u pacientů s diabetem: preklinické ověření role proteinu MSF</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů