Molecular characterization of primary colorectal cancers with progressive metastatic phenotype by oligonucleotide microarrays

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00017176" target="_blank" >RIV/00216224:14110/06:00017176 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Molecular characterization of primary colorectal cancers with progressive metastatic phenotype by oligonucleotide microarrays

Popis výsledku v původním jazyce

PURPOSE: Colorectal cancer (CRC) is one of the most common malignancies. Unfortunately a significant proportion of surgically cured patiens in the early stage of the disease develop progression and die from the disease. This study aimed to find individual up/down-regulated genes associated with progression and metastatic potential of colorectal cancers using low-density oligonucleotide microarrays. Molecular characterization of patients at high risk of cancer progression may assist to oncologists in treatment decision by selecting those patients who will need adjuvant chemotherapy. PATIENTS AND METHODS: Patients who underwent surgical resection were divided into different prognostic groups by disease-free survival (DFS&gt;36 month ? good prognosis; DFS&lt;36 month ? bad prognosis). Total RNA was extracted from each frozen tumor specimen and gene expression profiles were obtained using a human oligonucleotide microrray (SuperArray) spotted with 128 genes known to be involved in metastas

Název v anglickém jazyce

Molecular characterization of primary colorectal cancers with progressive metastatic phenotype by oligonucleotide microarrays

Popis výsledku anglicky

PURPOSE: Colorectal cancer (CRC) is one of the most common malignancies. Unfortunately a significant proportion of surgically cured patiens in the early stage of the disease develop progression and die from the disease. This study aimed to find individual up/down-regulated genes associated with progression and metastatic potential of colorectal cancers using low-density oligonucleotide microarrays. Molecular characterization of patients at high risk of cancer progression may assist to oncologists in treatment decision by selecting those patients who will need adjuvant chemotherapy. PATIENTS AND METHODS: Patients who underwent surgical resection were divided into different prognostic groups by disease-free survival (DFS&gt;36 month ? good prognosis; DFS&lt;36 month ? bad prognosis). Total RNA was extracted from each frozen tumor specimen and gene expression profiles were obtained using a human oligonucleotide microrray (SuperArray) spotted with 128 genes known to be involved in metastas

Druh

D - Stať ve sborníku

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/NR9076" target="_blank" >NR9076: Genomické profilování v predikci odpovědi na chemoradioterapii u pacientů s lokálně pokročilým karcinomem konečníku</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

sborník XX. BIOCHEMICKÝ ZJAZD

ISBN

80-969532-6-5

ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

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Název nakladatele

Slovenská společnost pro biochémiu a molekulárnu biologii, člen IUMBM a FEBS

Místo vydání

Piešťany

Místo konání akce

Piešťany, Slovenská republika

Datum konání akce

1. 1. 2006

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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