Vliv pohlaví na metabolickou aktivitu enzymatickeho systemu cytochromu P450 na modele izolovaných prerfundovaných jater.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00017778" target="_blank" >RIV/00216224:14110/06:00017778 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The influence of gender on metabolic activity of enzymatic system of cytochrome P450 in the model of isolated perfused rat liver.

Popis výsledku v původním jazyce

Interindividual variability of activity of oxidative and conjugating enzymes, especially the system of cytochrome P450, can be based on many different factors i.e. gender, age, genetic factors or interactions between simultaneously applied drugs. Such avariability may result in a different pharmacoterapeutical effectivity, adverse effects or toxicity of apllied drug. A suitable model for investigations on the activity of hepatic CYPs 450 and biotransformation processes is represented by the isolated perfused liver. As we expected, the activity of CYP subfamilies differed due to gender. CYP 2D2 activity in rat females was significantly higher than in males (Fig. 1). Also the final concentration of a marker metabolite (dextrorphan) in females was higheronly in CYP 2D2. The elevation was 5,7% in the 30th min, 33% in the 60th min and 34% in the 120th min. In contrast activity in CYP 3A subfamily in females was lower than in males. Next two isoforms of CYP450, used as markers were tolbuta

Název v anglickém jazyce

The influence of gender on metabolic activity of enzymatic system of cytochrome P450 in the model of isolated perfused rat liver.

Popis výsledku anglicky

Interindividual variability of activity of oxidative and conjugating enzymes, especially the system of cytochrome P450, can be based on many different factors i.e. gender, age, genetic factors or interactions between simultaneously applied drugs. Such avariability may result in a different pharmacoterapeutical effectivity, adverse effects or toxicity of apllied drug. A suitable model for investigations on the activity of hepatic CYPs 450 and biotransformation processes is represented by the isolated perfused liver. As we expected, the activity of CYP subfamilies differed due to gender. CYP 2D2 activity in rat females was significantly higher than in males (Fig. 1). Also the final concentration of a marker metabolite (dextrorphan) in females was higheronly in CYP 2D2. The elevation was 5,7% in the 30th min, 33% in the 60th min and 34% in the 120th min. In contrast activity in CYP 3A subfamily in females was lower than in males. Next two isoforms of CYP450, used as markers were tolbuta

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Homeostasis in Health and Diseases

ISSN

0960-7560

e-ISSN

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Svazek periodika

44

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

3

Strana od-do

128-130

Kód UT WoS článku

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EID výsledku v databázi Scopus

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