Diagnostic validity of skin biopsy in painful sensory neuropathy utilising intra- and subepidermal nerve fiber densities

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00017808" target="_blank" >RIV/00216224:14110/06:00017808 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Diagnostic validity of skin biopsy in painful sensory neuropathy utilising intra- and subepidermal nerve fiber densities

Popis výsledku v původním jazyce

Evaluation of intra-epidermal nerve fiber density (IENFD) has become a standard tool in the diagnosis of painful sensory neuropathy. However, changes in the density of the subepidermal nerve plexus (SENFD) have never been systematically studied in neuropathy patients. Intra- and subepidermal nerve fiber densities were examined using PGP 9.5-immunostaining of skin-punch biopsy samples from the distal calf in 99 consecutively-recruited patients with clinical symptoms of a painful sensory neuropathy and with abnormal thermal thresholds on quantitative sensory testing (QST), and in 37 age-matched healthy volunteers. Comparison of the groups demonstrated a clear reduction in both IENFD and SENFD in the neuropathy group compared to the healthy controls (p&lt;0.001). The diagnostic validity of IENFD and SENFD was assessed in receiver-operating characteristic curve (ROC) analysis. Using a cut-off value of 8.8 fibers/mm, the sensitivity of IENFD examination was 0.80 and the specificity 0.82.

Název v anglickém jazyce

Diagnostic validity of skin biopsy in painful sensory neuropathy utilising intra- and subepidermal nerve fiber densities

Popis výsledku anglicky

Evaluation of intra-epidermal nerve fiber density (IENFD) has become a standard tool in the diagnosis of painful sensory neuropathy. However, changes in the density of the subepidermal nerve plexus (SENFD) have never been systematically studied in neuropathy patients. Intra- and subepidermal nerve fiber densities were examined using PGP 9.5-immunostaining of skin-punch biopsy samples from the distal calf in 99 consecutively-recruited patients with clinical symptoms of a painful sensory neuropathy and with abnormal thermal thresholds on quantitative sensory testing (QST), and in 37 age-matched healthy volunteers. Comparison of the groups demonstrated a clear reduction in both IENFD and SENFD in the neuropathy group compared to the healthy controls (p&lt;0.001). The diagnostic validity of IENFD and SENFD was assessed in receiver-operating characteristic curve (ROC) analysis. Using a cut-off value of 8.8 fibers/mm, the sensitivity of IENFD examination was 0.80 and the specificity 0.82.

Druh

O - Ostatní výsledky

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů