Gene expression of the phenylethanolamine N-methyltransferase is differently modulated in cardiac atria and ventricles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00031735" target="_blank" >RIV/00216224:14110/06:00031735 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Gene expression of the phenylethanolamine N-methyltransferase is differently modulated in cardiac atria and ventricles

Popis výsledku v původním jazyce

Phenylethanolamine N-methyltransferase (PNMT) is a final enzyme in catecholamine synthesizing cascade that converts noradrenaline to adrenaline. Although most profuse in adrenal medulla, PNMT is expressed also in the heart, particularly in cardiac atriaand ventricles. In atria, the PNMT mRNA is much more abundant compared to ventricles. In this work we aimed to find out, whether there is difference in modulation of the PNMT gene expression in cardiac atria and ventricles. We used three methodological approaches - cold as a model of mild stress, hypoxia as a model of cardiac ischemic injury and transgenic rats with incorporated mouse renin gene [TGR (mREN-2)27], to determine involvement of renin-angiotensin pathway in the PNMT gene expression. We havefound that PNMT gene expression was modulated differently in cardiac atria and ventricles. In atria PNMT mRNA levels were increased by hypoxia, while cold stress decreased PNMT mRNA levels.

Název v anglickém jazyce

Gene expression of the phenylethanolamine N-methyltransferase is differently modulated in cardiac atria and ventricles

Popis výsledku anglicky

Phenylethanolamine N-methyltransferase (PNMT) is a final enzyme in catecholamine synthesizing cascade that converts noradrenaline to adrenaline. Although most profuse in adrenal medulla, PNMT is expressed also in the heart, particularly in cardiac atriaand ventricles. In atria, the PNMT mRNA is much more abundant compared to ventricles. In this work we aimed to find out, whether there is difference in modulation of the PNMT gene expression in cardiac atria and ventricles. We used three methodological approaches - cold as a model of mild stress, hypoxia as a model of cardiac ischemic injury and transgenic rats with incorporated mouse renin gene [TGR (mREN-2)27], to determine involvement of renin-angiotensin pathway in the PNMT gene expression. We havefound that PNMT gene expression was modulated differently in cardiac atria and ventricles. In atria PNMT mRNA levels were increased by hypoxia, while cold stress decreased PNMT mRNA levels.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

General Physiology and Biophysics

ISSN

0231-5882

e-ISSN

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Svazek periodika

25

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

000244957800002

EID výsledku v databázi Scopus

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