Haplotype-based association study between the region of 6p chromosome spanning the AGER - TNFA - LTA - NFKBIL1 - BAT1 and diabetic nephropathy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F07%3A00019402" target="_blank" >RIV/00216224:14110/07:00019402 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Haplotype-based association study between the region of 6p chromosome spanning the AGER - TNFA - LTA - NFKBIL1 - BAT1 and diabetic nephropathy

Popis výsledku v původním jazyce

Aims: Previously we identified certain haplotype in the AGER gene (encoding Receptor of Advanced Glycation End-products) as a risk factor for diabetic nephropathy (DN) [Kankova et al., Nephrol Dial Transpl 2005]. Recently, multiple SNPs in the BAT1, NFKBIL1 and LTA genes have been found associated with myocardial infarction in the genome-wide association study. Detail analysis of the given MHC III region on chromosome 6p spanning the AGER - TNFA - LTA - NFKBIL1 - BAT1 loci could further elucidate the character of association and help to identify causal variant. The aims of the study were (1) to perform more detail haplotype analysis based on genotypes of multiple single nucleotide polymorphisms in the five genes and (2) to ascertain eventual association between certain haplotype(s) with DN and identify en eventual causal variant among them. Methods: A total of 600 diabetic subjects were included in the cross-sectional case - control study.

Název v anglickém jazyce

Haplotype-based association study between the region of 6p chromosome spanning the AGER - TNFA - LTA - NFKBIL1 - BAT1 and diabetic nephropathy

Popis výsledku anglicky

Aims: Previously we identified certain haplotype in the AGER gene (encoding Receptor of Advanced Glycation End-products) as a risk factor for diabetic nephropathy (DN) [Kankova et al., Nephrol Dial Transpl 2005]. Recently, multiple SNPs in the BAT1, NFKBIL1 and LTA genes have been found associated with myocardial infarction in the genome-wide association study. Detail analysis of the given MHC III region on chromosome 6p spanning the AGER - TNFA - LTA - NFKBIL1 - BAT1 loci could further elucidate the character of association and help to identify causal variant. The aims of the study were (1) to perform more detail haplotype analysis based on genotypes of multiple single nucleotide polymorphisms in the five genes and (2) to ascertain eventual association between certain haplotype(s) with DN and identify en eventual causal variant among them. Methods: A total of 600 diabetic subjects were included in the cross-sectional case - control study.

Druh

O - Ostatní výsledky

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/KJB501620601" target="_blank" >KJB501620601: Funkční analýza rizikového haplotypu RAGE genu a jeho role v patogenezi hyperglykemií indukovaných změn</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů