Tři polymorfismy v genu pro RXR receptor u pacientů s psoriasis en plaque a psoriasis guttata

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F07%3A00021770" target="_blank" >RIV/00216224:14110/07:00021770 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Three Retionoid X Receptor Gene Polymorphisms in Plaque Psoriasis and Psoriasis Guttata

Popis výsledku v původním jazyce

Aim: Polymorphisms in RXRs are very interesting from the point of view of possible association of their variability with psoriasis. Methods: The total of 293 patients with plaque psoriasis, 82 patients with psoriasis guttata and 202 control subjects havebeen enrolled in this study focused on three polymorphisms in RXRA and RXRB genes associations. Results: A marginally significant increase in AA allelic frequency of RXRA A(39526)AA polymorphism in plaque psoriatic men compared to healthy ones was proved. In women with psoriasis guttata, the higher risk for genotypes AA and TT in RXRB 3+ 140A/T polymorphism compared to healthy women was identified ( Pcorr=0.01). The genotypes A/A and AA/AA are more frequent in plaque psoriasis patients with positive family history of psoriasis compared to the patients with negative family history of psoriasis (Pcorr=0.02). The A/A genotype is more frequent in patients with plaque psoriasis and repeated tonsillitis/tonsillectomia (P=0.02). In RXRB polym

Název v anglickém jazyce

Three Retionoid X Receptor Gene Polymorphisms in Plaque Psoriasis and Psoriasis Guttata

Popis výsledku anglicky

Aim: Polymorphisms in RXRs are very interesting from the point of view of possible association of their variability with psoriasis. Methods: The total of 293 patients with plaque psoriasis, 82 patients with psoriasis guttata and 202 control subjects havebeen enrolled in this study focused on three polymorphisms in RXRA and RXRB genes associations. Results: A marginally significant increase in AA allelic frequency of RXRA A(39526)AA polymorphism in plaque psoriatic men compared to healthy ones was proved. In women with psoriasis guttata, the higher risk for genotypes AA and TT in RXRB 3+ 140A/T polymorphism compared to healthy women was identified ( Pcorr=0.01). The genotypes A/A and AA/AA are more frequent in plaque psoriasis patients with positive family history of psoriasis compared to the patients with negative family history of psoriasis (Pcorr=0.02). The A/A genotype is more frequent in patients with plaque psoriasis and repeated tonsillitis/tonsillectomia (P=0.02). In RXRB polym

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FO - Dermatovenerologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Dermatology

ISSN

1018-8665

e-ISSN

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Svazek periodika

02/2007

Číslo periodika v rámci svazku

214

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

118-124

Kód UT WoS článku

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EID výsledku v databázi Scopus

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