Jsou v populaci časté polymorfismy v genu pro leptin asociovány s výskytem restenózy po implantaci stentu?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F07%3A00022111" target="_blank" >RIV/00216224:14110/07:00022111 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Are common leptin promoter polymorphisms associated with restenosis after coronary stenting?

Popis výsledku v původním jazyce

The hypertrophy of vascular smooth muscle cells as well as neointimal proliferation is critical in vascular remodeling, whereas leptin has proved to play an important role recently. The aim of the study was to investigate possible associations of two common leptin gene polymorphisms with restenosis after percutaneous coronary intervention (PCI). To study the association of two promoter polymorphisms, LEP 2548 G/A and LEP 188 C/A (dbSNP ID rs7799039 and rs791620) with neointimal proliferation in humans,98 consecutive patients undergoing stenting into small coronary arteries (&lt;3 mm) were genotyped. After a 6 month follow up, the restenosis rate was estimated. Restenosis &gt;50% occurred in 33.3% of patients carrying both A alleles, 33.3% of carriersof A and C alleles, and 31.4% of carriers of two CC alleles of LEP 188 C/A polymorphism; and in 25.0% of patients with AA, 32.7% with AG, and 30.4% with GG genotype of LEP 2548 G/A polymorphism. Interestingly, the heterozygote AG genotype

Název v anglickém jazyce

Are common leptin promoter polymorphisms associated with restenosis after coronary stenting?

Popis výsledku anglicky

The hypertrophy of vascular smooth muscle cells as well as neointimal proliferation is critical in vascular remodeling, whereas leptin has proved to play an important role recently. The aim of the study was to investigate possible associations of two common leptin gene polymorphisms with restenosis after percutaneous coronary intervention (PCI). To study the association of two promoter polymorphisms, LEP 2548 G/A and LEP 188 C/A (dbSNP ID rs7799039 and rs791620) with neointimal proliferation in humans,98 consecutive patients undergoing stenting into small coronary arteries (&lt;3 mm) were genotyped. After a 6 month follow up, the restenosis rate was estimated. Restenosis &gt;50% occurred in 33.3% of patients carrying both A alleles, 33.3% of carriersof A and C alleles, and 31.4% of carriers of two CC alleles of LEP 188 C/A polymorphism; and in 25.0% of patients with AA, 32.7% with AG, and 30.4% with GG genotype of LEP 2548 G/A polymorphism. Interestingly, the heterozygote AG genotype

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Heart Vessels

ISSN

0910-8327

e-ISSN

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Svazek periodika

2007

Číslo periodika v rámci svazku

22(5)

Stát vydavatele periodika

JP - Japonsko

Počet stran výsledku

6

Strana od-do

310-5

Kód UT WoS článku

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EID výsledku v databázi Scopus

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