Co-Expression by Keratinocytes of Migration Stimulating Factor (MSF) and a Functional Inhibitor of its Bioactivity (MSFI)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F07%3A00022626" target="_blank" >RIV/00216224:14110/07:00022626 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Co-Expression by Keratinocytes of Migration Stimulating Factor (MSF) and a Functional Inhibitor of its Bioactivity (MSFI)

Popis výsledku v původním jazyce

Data presented in this communication indicate that MSF is constitutively expressed by keratinocytes in culture, but is rendered functionally inactive by the co-secretion of an inhibitor (MSFI). This inhibitor was identified as NGAL. MSFI activity was found in NGAL obtained from four different sources: keratinocytes, neutrophils and recombinant protein isolated from both procaryotic and eucaryotic sources. This is a novel activity of NGAL which does not seem to be mediated by previously reported mechanisms, such as iron transport or direct protein-protein binding.

Název v anglickém jazyce

Co-Expression by Keratinocytes of Migration Stimulating Factor (MSF) and a Functional Inhibitor of its Bioactivity (MSFI)

Popis výsledku anglicky

Data presented in this communication indicate that MSF is constitutively expressed by keratinocytes in culture, but is rendered functionally inactive by the co-secretion of an inhibitor (MSFI). This inhibitor was identified as NGAL. MSFI activity was found in NGAL obtained from four different sources: keratinocytes, neutrophils and recombinant protein isolated from both procaryotic and eucaryotic sources. This is a novel activity of NGAL which does not seem to be mediated by previously reported mechanisms, such as iron transport or direct protein-protein binding.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/LZ1K03019" target="_blank" >LZ1K03019: Zlepšení hojení ran u pacientů s diabetem: preklinické ověření role proteinu MSF</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Experimental Cell Research

ISSN

0014-4827

e-ISSN

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Svazek periodika

313

Číslo periodika v rámci svazku

20

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

4145-4157

Kód UT WoS článku

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EID výsledku v databázi Scopus

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